Phenotypes associated with this allele

• Allele Symbol: Sct^tm1Inis
• Allele Name: targeted mutation 1, Ichiko Nishijima
• Allele ID: MGI:3815315
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sct^tm1Inis/Sct^tm1Inis	involves: 129S7/SvEvBrd * C57BL/6	MGI:3815317

Genotype
MGI:3815317

hm1

• Allelic Composition: Sct^tm1Inis/Sct^tm1Inis
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:140787 )

N • despite defects in hippocampal physiology, there is no difference in the number of dendritic branches or in the morphology of spines on apical dendrites in pyramidal neurons in the CA1 region

reduced long-term potentiation ( J:140787 )

• significant reduction in hippocampal long term potentiation immediately following high frequency stimulation and throughout the induction and maintenance phases

decreased post-tetanic potentiation ( J:140787 )

• reduction in post-tetanic potentiation

decreased paired-pulse facilitation ( J:140787 )

• significant deficit in paired pulse facilitation at both 20 ms and 40 ms inter-pulse intervals