Phenotypes associated with this allele

• Allele Symbol: Tg(MECP2)3Hzo
• Allele Name: transgene insertion 3, Huda Y Zoghbi
• Allele ID: MGI:3815541
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(MECP2)3Hzo/0	either: (FVB/N x 129S6/SvEvTac)F1 or (FVB/N x C57BL/6J)F1	MGI:5314412
tg2	Tg(MECP2)3Hzo/0	involves: FVB	MGI:3817184

Genotype
MGI:5314412

tg1

• Allelic Composition: Tg(MECP2)3Hzo/0
• Genetic Background: either: (FVB/N x 129S6/SvEvTac)F1 or (FVB/N x C57BL/6J)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased anxiety-related response ( J:181213 )

• mutants exhibit anxiety-like behavior in the elevated plus maze

• mutants spend less time in the lit compartment of the light/dark box compared to wild-type mice indicating anxiety-like behavior

decreased locomotor activity ( J:181213 )

• mutants travel less than wild-type mice in the open field

abnormal social investigation ( J:181213 )

• mutants are less interested in their familiar or novel partner mice in the partition test for social interaction and recognition

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
syndromic X-linked intellectual disability Lubs type		DOID:0060799	OMIM:300260	J:181213

Genotype
MGI:3817184

tg2

• Allelic Composition: Tg(MECP2)3Hzo/0
• Genetic Background: involves: FVB

mortality/aging

postnatal lethality ( J:94407 )

• majority of males die by 3 weeks

behavior/neurological

increased aggression ( J:94407 )

• increased propensity to bite

limb grasping ( J:94407 )

• forepaw clasping when lifted by tail

decreased locomotor activity ( J:94407 )

• characterized by freezing behavior

skeleton

kyphosis ( J:94407 )