Analysis Tools|
Allele Symbol Allele Name Allele ID |
Batf3tm1Kmm targeted mutation 1, Kenneth M Murphy MGI:3817232 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• homozygotes retain an enhanced antibody response to anti-Clec9a coupled antigen
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• reduced cytotoxic T cell response to anti-Clec9a coupled antigen
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• reduced cytotoxic T cell response to anti-Clec9a coupled antigen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice lack CD8a+ dendritic cell subsets
• bone marrow chimera experiments indicate a lack of CD8a+ DCs is due to a cell-intrinsic effect of the mutant locus
• in vitro bone marrow differentiation cultures fail to generate CD24+ Sirp-alpha- DCs that are similar to CD8a+ DC
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• mice lack splenic CD11chiCD8a+DEC205+ dendritic cells
• mice have a loss of CD11chiCD11bdull DCs and CD11chi CD8a+CD24+ DCs
• mice have normal populations of CD4+ and CD8a-CD4- conventional DC subsets
• lymph nodes and thymi lack CD8a+ DC subsets
• CD103-+DEC205+CD8a-CD11blo/- dermal DC numbers are reduced 5-fold in draining lymph nodes of the skin
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• mice fail to develop West Nile Virus (WNV)-specific memory CD8+ T cells after infection with the virus
• the number of CD8+CD44hiCD62Llowcells memory cells is about half-that of wild-type mice before infection and is five-fold less after infection
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• transplanted syngenic fibrosarcomas grow in size instead of being reapidly rejected as happens in control mice
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• CD8+ T cells from mice infected with West Nile virus (WNV) have defective IFN-gamma secretion when cultured with WNV-peptide
• bone marrow chimera studies demonstrate that defective cytolytic activity is not intrinsic to the CD8+ T cells but rather defective dendritic cell function
• infiltrating CD8+ T cells fail to infiltrate transplanted syngenic tumors
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• CD8+ T cells from mice infected with West Nile virus (WNV) have defective killing of WNV peptide-loaded target cells
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• conventional DCs fail to secrete IL-12 after TL3 stimulation but have normal responses to TLR4 and TLR9 stimulation
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• conventional DCs are unable to cross-present (i.e. take up protein, process into peptide and present) ovalbumin antigen to ova-specific CD8+ T cells
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• mice lack CD8a+ dendritic cell subsets
• bone marrow chimera experiments indicate a lack of CD8a+ DCs is due to a cell-intrinsic effect of the mutant locus
• in vitro bone marrow differentiation cultures fail to generate CD24+ Sirp-alpha- DCs that are similar to CD8a+ DC
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• mice lack splenic CD11chiCD8a+DEC205+ dendritic cells
• mice have a loss of CD11chiCD11bdull DCs and CD11chi CD8a+CD24+ DCs
• mice have normal populations of CD4+ and CD8a-CD4- conventional DC subsets
• lymph nodes and thymi lack CD8a+ DC subsets
• CD103-+DEC205+CD8a-CD11blo/- dermal DC numbers are reduced 5-fold in draining lymph nodes of the skin
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• mice fail to develop West Nile Virus (WNV)-specific memory CD8+ T cells after infection with the virus
• the number of CD8+CD44hiCD62Llowcells memory cells is about half-that of wild-type mice before infection and is five-fold less after infection
|
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• CD8+ T cells from mice infected with West Nile virus (WNV) have defective IFN-gamma secretion when cultured with WNV-peptide
• bone marrow chimera studies demonstrate that defective cytolytic activity is not intrinsic to the CD8+ T cells but rather defective dendritic cell function
• infiltrating CD8+ T cells fail to infiltrate transplanted syngenic tumors
|
|
• CD8+ T cells from mice infected with West Nile virus (WNV) have defective killing of WNV peptide-loaded target cells
|
|
• mice lack CD8a+ dendritic cell subsets
• bone marrow chimera experiments indicate a lack of CD8a+ DCs is due to a cell-intrinsic effect of the mutant locus
• in vitro bone marrow differentiation cultures fail to generate CD24+ Sirp-alpha- DCs that are similar to CD8a+ DC
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in reconstitution assays, CD8alpha+ dendritic cells generate from transplanted bone marrow cells fail to survive long-term
• CD8alpha+ dendritic cells exhibit impaired cell-associated cross-presentation compared with control cells
• however, cells exhibit normal soluble cross-presentation and cell-associated antigen cross-presentation during GVHD or HSV-1 viral antigens
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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