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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Nes-cre/ERT2)4Imayo
transgene insertion 4, Itaru Imayoshi
MGI:3817325
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Eno2tm1(DTA)Hsak/Eno2tm1(DTA)Hsak
Tg(Nes-cre/ERT2)4Imayo/0
involves: C57BL/6 MGI:3817329
tg2
Tg(Nes-cre/ERT2)4Imayo/0 involves: C57BL/6 MGI:6403908


Genotype
MGI:3817329
cn1
Allelic
Composition
Eno2tm1(DTA)Hsak/Eno2tm1(DTA)Hsak
Tg(Nes-cre/ERT2)4Imayo/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eno2tm1(DTA)Hsak mutation (1 available); any Eno2 mutation (55 available)
Tg(Nes-cre/ERT2)4Imayo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• following treatment with tamoxifen, mice exhibit decreased granule cell density in the dentate gyrus instead of the increase observed in wild-type mice
• however, neuronal circuits in the dentate gyrus are normal
• 3 weeks following treatment with tamoxifen, mice exhibit ablation of newly formed neurons in the olfactory bulb that becomes more severe at 6 and 12 weeks of treatment
• following treatment with tamoxifen, mice exhibit ablation of newly forming neurons
• following treatment with tamoxifen, neuroblasts at the entry site of the rostral migratory stream exhibit markers of apoptosis
• 3 weeks following treatment with tamoxifen, mice exhibit ablation of newly formed neurons in the olfactory bulb that becomes more severe at 6 and 12 weeks of treatment
• following treatment with tamoxifen, mice exhibit a loss of granule cells in deep regions while superficial neurons are preserved
• 3 weeks following treatment with tamoxifen, mice exhibit loss of granule neurons in the olfactory bulb
• following treatment with tamoxifen, mice exhibit decreased granule cell density in the dentate gyrus compared to in wild-type mice

behavior/neurological
N
• despite ablation of olfactory neurons, mice exhibit normal behavior towards wild-type mice and normal odor-associated memory
• tamoxifen treated mice exhibit reduced freezing responses compared to wild-type mice
• however, cue conditioning is normal
• in a Barnes maze spatial memory test, tamoxifen treated mice exhibit impaired retention of spatial memory compared to wild-type mice




Genotype
MGI:6403908
tg2
Allelic
Composition
Tg(Nes-cre/ERT2)4Imayo/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre/ERT2)4Imayo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• miscarrages in mice from dams treated with a high dose of tamoxifen beginning at E10.5

nervous system
• at E19.5 in the subventricular zone of tamoxifen-treated mice
• in mice from dams treated with a high dose of tamoxifen beginning at E10.5
• in mice from dams treated with a high dose of tamoxifen beginning at E10.5

cellular
• at E19.5 in the subventricular zone of tamoxifen-treated mice





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory