Phenotypes associated with this allele

• Allele Symbol: Stx1a^tm1Gwz
• Allele Name: targeted mutation 1, Gerald W Zamponi
• Allele ID: MGI:3817409
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stx1a^tm1Gwz/Stx1a^tm1Gwz	Not Specified	MGI:3817412

Genotype
MGI:3817412

hm1

• Allelic Composition: Stx1a^tm1Gwz/Stx1a^tm1Gwz
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality at weaning, incomplete penetrance ( J:141037 )

• only 4 homozygous offspring out of 224 from heterozygous breedings (one male and 3 females)

lethality throughout fetal growth and development, incomplete penetrance ( J:141037 )

• only 3 out of 37 homozygous embryos found at E15

growth/size/body

embryonic growth retardation ( J:141037 )

• E15 fetuses lack limbs, tail and facial features

decreased body weight ( J:141037 )

• surviving homozygotes show a reduced body weight over the 2 month observation period

decreased fetal size ( J:141037 )

• significantly smaller than controls at E15

behavior/neurological

behavior/neurological phenotype ( J:141037 )

N • behavior normal on a Morris water maze, elevated plus maze, open field test, passive and active avoidance tests

embryo

embryonic growth retardation ( J:141037 )

• E15 fetuses lack limbs, tail and facial features