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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Naip5tm1Vnce
targeted mutation 1 Russell E Vance
MGI:3817439
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Naip5tm1Vnce/Naip5tm1Vnce C57BL/6-Naip5tm1Vnce MGI:3817442


Genotype
MGI:3817442
hm1
Allelic
Composition		 Naip5tm1Vnce/Naip5tm1Vnce
Genetic
Background		 C57BL/6-Naip5tm1Vnce
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Naip5tm1Vnce mutation (0 available); any Naip5 mutation (103 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:141008 )
• macrophage fail to release Il1 beta after infection with Legionella pneumophila

cellular
decreased cell death ( J:141008 )
• macrophage fail to undergo pyroptotic cell death after infection with Legionella pneumophila




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory