All Phenotypes Zbtb7b<tm1Itan> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Zbtb7b^tm1Itan/Zbtb7b^tm1Tani	involves: 129 * C57BL/6	MGI:3817579
ht2	Zbtb7b^tm1Itan/Zbtb7b^tm2Itan	involves: 129 * C57BL/6	MGI:3817583
cx3	Rr96^tm2Litt/Rr96⁺ Zbtb7b^tm1Itan/Zbtb7b^tm1Tani	involves: 129 * 129P2/OlaHsd * C57BL/6	MGI:3817581

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased double-negative T cell number ( J:141142 )

• the percentage of double negative thymocytes bearing Tcr-beta chains is doubled

• an unusual double negative T cell population is found in the lymph nodes of these mice

increased CD8-positive, alpha-beta T cell number ( J:141142 )

• single positive CD8⁺ T cell numbers are increased in the thymus and lymph nodes

abnormal CD4-positive, alpha beta T cell morphology ( J:141142 )

• CD4⁺ T cells that express high levels of GFP have the ability to differentiate into CD8⁺ T cells in vitro

• CD4⁺ T cells that express high levels of GFP have the ability to differentiate into CD8⁺,or CD4⁺CD8⁺, or CD4^-CD8^- T cells when transferred into lymphocyte deficient hosts

decreased CD4-positive, alpha-beta T cell number ( J:141142 )

• single positive CD4⁺ T cell numbers are decreased in both in the thymus and lymph nodes

abnormal CD4-positive, alpha-beta T cell physiology ( J:141142 )

• T-helper cells produce much less IL-4, have increased expression of IFN-gamma, and fail to express CD154 upon stimulation suggesting CD4 T cells from these mice have characteristics similar to CD8 T cells

hematopoietic system

increased double-negative T cell number ( J:141142 )

• the percentage of double negative thymocytes bearing Tcr-beta chains is doubled

• an unusual double negative T cell population is found in the lymph nodes of these mice

increased CD8-positive, alpha-beta T cell number ( J:141142 )

• single positive CD8⁺ T cell numbers are increased in the thymus and lymph nodes

abnormal CD4-positive, alpha beta T cell morphology ( J:141142 )

• CD4⁺ T cells that express high levels of GFP have the ability to differentiate into CD8⁺ T cells in vitro

• CD4⁺ T cells that express high levels of GFP have the ability to differentiate into CD8⁺,or CD4⁺CD8⁺, or CD4^-CD8^- T cells when transferred into lymphocyte deficient hosts

decreased CD4-positive, alpha-beta T cell number ( J:141142 )

• single positive CD4⁺ T cell numbers are decreased in both in the thymus and lymph nodes

abnormal CD4-positive, alpha-beta T cell physiology ( J:141142 )

Allelic Composition	Zbtb7b^tm1Itan/Zbtb7b^tm2Itan
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb7b^tm1Itan mutation (0 available); any Zbtb7b mutation (26 available)
Zbtb7b^tm2Itan mutation (0 available); any Zbtb7b mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased double-negative T cell number ( J:141142 )

• an unusual double negative T cell population is found in the lymph nodes of these mice

• these double negative T cells all express GFP

decreased CD4-positive, alpha-beta T cell number ( J:141142 )

• peripheral CD4⁺ T cell numbers are reduced by almost two-thirds compared to controls with less dramatic differences in the thymus

increased CD8-positive, alpha-beta T cell number ( J:141142 )

• single positive CD8⁺ T cell numbers are increased in the thymus and lymph nodes

• some CD8⁺ T cells express GFP

immune system

increased double-negative T cell number ( J:141142 )

• an unusual double negative T cell population is found in the lymph nodes of these mice

• these double negative T cells all express GFP

decreased CD4-positive, alpha-beta T cell number ( J:141142 )

• peripheral CD4⁺ T cell numbers are reduced by almost two-thirds compared to controls with less dramatic differences in the thymus

increased CD8-positive, alpha-beta T cell number ( J:141142 )

• single positive CD8⁺ T cell numbers are increased in the thymus and lymph nodes

• some CD8⁺ T cells express GFP

Allelic Composition	Rr96^tm2Litt/Rr96⁺ Zbtb7b^tm1Itan/Zbtb7b^tm1Tani
Genetic Background	involves: 129 * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr96^tm2Litt mutation (0 available); any Rr96 mutation (0 available)
Zbtb7b^tm1Itan mutation (0 available); any Zbtb7b mutation (26 available)
Zbtb7b^tm1Tani mutation (1 available); any Zbtb7b mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal double-negative T cell morphology ( J:141142 )

• the increase in double negative T cells observed in Zbtb7b^tm1Itan / Zbtb7b^tm1Tani compound heterozygotes is not observed in these mice

decreased CD8-positive, alpha-beta T cell number ( J:141142 )

• CD8⁺ T cells are almost absent in the periphery

hematopoietic system

abnormal double-negative T cell morphology ( J:141142 )

• the increase in double negative T cells observed in Zbtb7b^tm1Itan / Zbtb7b^tm1Tani compound heterozygotes is not observed in these mice

decreased CD8-positive, alpha-beta T cell number ( J:141142 )

• CD8⁺ T cells are almost absent in the periphery

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