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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Zbtb7btm2Itan
targeted mutation 2, Ichiro Taniuchi
MGI:3817518
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Zbtb7btm2Itan/Zbtb7b+ involves: 129 * C57BL/6 MGI:3817588
ht2
Zbtb7btm1Itan/Zbtb7btm2Itan involves: 129 * C57BL/6 MGI:3817583


Genotype
MGI:3817588
ht1
Allelic
Composition
Zbtb7btm2Itan/Zbtb7b+
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb7btm2Itan mutation (0 available); any Zbtb7b mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• while there was a decrease in GFP expression by thymocytes differentiating into CD4 + T cells, no phenotypic abnormalities are reported




Genotype
MGI:3817583
ht2
Allelic
Composition
Zbtb7btm1Itan/Zbtb7btm2Itan
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb7btm1Itan mutation (0 available); any Zbtb7b mutation (26 available)
Zbtb7btm2Itan mutation (0 available); any Zbtb7b mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• an unusual double negative T cell population is found in the lymph nodes of these mice
• these double negative T cells all express GFP
• peripheral CD4+ T cell numbers are reduced by almost two-thirds compared to controls with less dramatic differences in the thymus
• single positive CD8+ T cell numbers are increased in the thymus and lymph nodes
• some CD8+ T cells express GFP

immune system
• an unusual double negative T cell population is found in the lymph nodes of these mice
• these double negative T cells all express GFP
• peripheral CD4+ T cell numbers are reduced by almost two-thirds compared to controls with less dramatic differences in the thymus
• single positive CD8+ T cell numbers are increased in the thymus and lymph nodes
• some CD8+ T cells express GFP





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory