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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(PGK1-KITLG*220)441Daw
transgene insertion 441, David A Williams
MGI:3817558
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		KitlSl/Kitl+
Tg(PGK1-KITLG*220)441Daw/0 		involves: C3H MGI:3817636
cx2
 		KitW/Kit+
Tg(PGK1-KITLG*220)441Daw/0 		involves: C3H/HeJ MGI:3817635
tg3
 		Tg(PGK1-KITLG*220)441Daw/Tg(PGK1-KITLG*220)441Daw C3H/HeJ-Tg(PGK1-KITLG*220)441Daw MGI:3817633


Genotype
MGI:3817636
cx1
Allelic
Composition		 KitlSl/Kitl+
Tg(PGK1-KITLG*220)441Daw/0
Genetic
Background		 involves: C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitlSl mutation (3 available); any Kitl mutation (94 available)
Tg(PGK1-KITLG*220)441Daw mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal coat/hair pigmentation ( J:32600 )
• 18% of offspring show more severe pigment loss than either parental strain

hematopoietic system
decreased mast cell number ( J:32600 )
• numbers of connective tissue mast cells are greatly reduced relative to controls

immune system
decreased mast cell number ( J:32600 )
• numbers of connective tissue mast cells are greatly reduced relative to controls

integument
abnormal coat/hair pigmentation ( J:32600 )
• 18% of offspring show more severe pigment loss than either parental strain




Genotype
MGI:3817635
cx2
Allelic
Composition		 KitW/Kit+
Tg(PGK1-KITLG*220)441Daw/0
Genetic
Background		 involves: C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitW mutation (10 available); any Kit mutation (182 available)
Tg(PGK1-KITLG*220)441Daw mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal coat/hair pigmentation ( J:32600 )
• 46% of mice show coat color similar to hemizygous transgenics or heterozygous KitW animals, while 29% show wild-type agouti coat coloring
• 25% of double mutants have a more severe deficiency in coat color pigmentation with large areas of hypopigmentation

hematopoietic system
decreased mast cell number ( J:32600 )
• numbers of connective tissue mast cells are greatly reduced relative to controls

immune system
decreased mast cell number ( J:32600 )
• numbers of connective tissue mast cells are greatly reduced relative to controls

integument
abnormal coat/hair pigmentation ( J:32600 )
• 46% of mice show coat color similar to hemizygous transgenics or heterozygous KitW animals, while 29% show wild-type agouti coat coloring
• 25% of double mutants have a more severe deficiency in coat color pigmentation with large areas of hypopigmentation




Genotype
MGI:3817633
tg3
Allelic
Composition		 Tg(PGK1-KITLG*220)441Daw/Tg(PGK1-KITLG*220)441Daw
Genetic
Background		 C3H/HeJ-Tg(PGK1-KITLG*220)441Daw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(PGK1-KITLG*220)441Daw mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
head blaze ( J:32600 )
• mice have prominent white head blaze (diamond-shaped white spot)
belly spot ( J:32600 )
• belly spot is larger than in heterozygous mice
variable body spotting ( J:32600 )
• mice show secondary spotting over cervical region and occasionally elsewhere

hematopoietic system
abnormal thymus morphology ( J:32600 )
• development is abnormal in homozygotes

immune system
abnormal thymus morphology ( J:32600 )
• development is abnormal in homozygotes

integument
head blaze ( J:32600 )
• mice have prominent white head blaze (diamond-shaped white spot)
belly spot ( J:32600 )
• belly spot is larger than in heterozygous mice
variable body spotting ( J:32600 )
• mice show secondary spotting over cervical region and occasionally elsewhere

endocrine/exocrine glands
abnormal thymus morphology ( J:32600 )
• development is abnormal in homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory