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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zbtb7btm1.1Rbo
targeted mutation 1.1, Remy Bosselut
MGI:3817628
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zbtb7btm1.1Rbo/Zbtb7btm1.1Rbo Not Specified MGI:3817638
cx2
 		Tg(TcrAND)53Hed/?
Zbtb7btm1.1Rbo/Zbtb7btm1.1Rbo 		involves: C57BL/6 * SJL MGI:3817639


Genotype
MGI:3817638
hm1
Allelic
Composition		 Zbtb7btm1.1Rbo/Zbtb7btm1.1Rbo
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb7btm1.1Rbo mutation (0 available); any Zbtb7b mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:141145 )
• the thymus contains a large CD4+CD8low population that has a high TCR expression and high CD24 expression
decreased CD4-positive, alpha-beta T cell number ( J:141145 )
• CD4 T cell numbers are severely reduced in the lymph nodes and spleen
abnormal CD8-positive, alpha-beta T cell number ( J:141145 )
• CD8 T cell numbers are increased in the lymph nodes and spleen by 2- to 5- fold

hematopoietic system
abnormal T cell differentiation ( J:141145 )
• the thymus contains a large CD4+CD8low population that has a high TCR expression and high CD24 expression
decreased CD4-positive, alpha-beta T cell number ( J:141145 )
• CD4 T cell numbers are severely reduced in the lymph nodes and spleen
abnormal CD8-positive, alpha-beta T cell number ( J:141145 )
• CD8 T cell numbers are increased in the lymph nodes and spleen by 2- to 5- fold




Genotype
MGI:3817639
cx2
Allelic
Composition		 Tg(TcrAND)53Hed/?
Zbtb7btm1.1Rbo/Zbtb7btm1.1Rbo
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcrAND)53Hed mutation (2 available)
Zbtb7btm1.1Rbo mutation (0 available); any Zbtb7b mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:141145 )
• T cells expressing the transgenic MHC class II-restricted TCR show diversion from the CD4+ lineage to the CD8+ lineage

hematopoietic system
abnormal T cell differentiation ( J:141145 )
• T cells expressing the transgenic MHC class II-restricted TCR show diversion from the CD4+ lineage to the CD8+ lineage




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory