mortality/aging
• mice die between E10.5 and E12.5
|
embryo
• at E9.5, yolk sacs fail to form an organized vascular network and blood cells moved slowly compared to in wild-type mice
|
• at E9.5
|
• at E9.5
|
• at E9.5, head mesenchyme exhibits reduced cellularity and cystic degeneration unlike in wild-type mice
|
• at E9.5
|
cardiovascular system
• at E9.5, yolk sacs fail to form an organized vascular network and blood cells moved slowly compared to in wild-type mice
|
• at E9.5
|
hemorrhage
(
J:184206
)
• at E9.5, mice exhibit blood cell accumulation in the head and trunk region
|
nervous system
• at E9.5
|
cellular
• in some neuroepithelial and mesenchymal cells in the head at E9.5
|
homeostasis/metabolism
• at E9.5
|
growth/size/body
• at E9.5
|
• at E9.5, head mesenchyme exhibits reduced cellularity and cystic degeneration unlike in wild-type mice
|