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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxp3m1Btlr
mutation 1, Bruce Beutler
MGI:3817855
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Foxp3m1Btlr/Foxp3m1Btlr C57BL/6J-Foxp3m1Btlr MGI:3817867
ht2
 		Foxp3m1Btlr/Foxp3+ C57BL/6J-Foxp3m1Btlr MGI:3817866
ot3
 		Foxp3m1Btlr/Y C57BL/6J-Foxp3m1Btlr MGI:3817856


Genotype
MGI:3817867
hm1
Allelic
Composition		 Foxp3m1Btlr/Foxp3m1Btlr
Genetic
Background		 C57BL/6J-Foxp3m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3m1Btlr mutation (0 available); any Foxp3 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:141212 )
N
• no homozygous mutant female pups have been observed




Genotype
MGI:3817866
ht2
Allelic
Composition		 Foxp3m1Btlr/Foxp3+
Genetic
Background		 C57BL/6J-Foxp3m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3m1Btlr mutation (0 available); any Foxp3 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:141212 )
• female mice heterozygous for this mutation appear normal in appearance and behavior and are fertile




Genotype
MGI:3817856
ot3
Allelic
Composition		 Foxp3m1Btlr/Y
Genetic
Background		 C57BL/6J-Foxp3m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3m1Btlr mutation (0 available); any Foxp3 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:141212 )
• male mice hemizygous for this mutation survive at least to 8 weeks of age

reproductive system
azoospermia ( J:141212 )
• hemizygous males produce no sperm
abnormal reproductive system development ( J:141212 )
• genitalia of hemizygous male mice are small and shriveled

growth/size/body
decreased body size ( J:141212 )
• hemizygous males are smaller than their littermates and appear unhealthy

integument
alopecia ( J:141212 )
• one mouse lost skin and hair from the anterior body at about 7 weeks of age
dry skin ( J:141212 )
• the skin of the ears and tail is shriveled and hardened
scaly skin ( J:141212 )
• the skin of the tail appears scaly
skin lesions ( J:141212 )
• the skin of the tail exhibits open wounds and scar tissue
• one mouse lost skin and hair from the anterior body at about 7 weeks of age

cellular
azoospermia ( J:141212 )
• hemizygous males produce no sperm




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory