Phenotypes associated with this allele

• Allele Symbol: Cdx1^tm1Lhn
• Allele Name: targeted mutation 1, David Lohnes
• Allele ID: MGI:3817874
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdx1^tm1Lhn/Cdx1^tm1Lhn	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3817889
ht2	Cdx1^tm1Lhn/Cdx1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3817887
ht3	Cdx1^tm1Lhn/Cdx1^tm1Pgr	involves: 129 * C57BL/6	MGI:3817893
cx4	Cdx1^tm1Lhn/Cdx1^+ Rarg^tm1Ipc/Rarg^tm1Ipc	involves: 129 * C57BL/6	MGI:3817900
cx5	Cdx1^tm1Lhn/Cdx1^tm1Lhn Rarg^tm1Ipc/Rarg^tm1Ipc	involves: 129 * C57BL/6	MGI:3817901
cx6	Cdx1^tm1Lhn/Cdx1^tm1Lhn Rarg^tm1Ipc/Rarg^+	involves: 129 * C57BL/6	MGI:3817902

Genotype
MGI:3817889

hm1

• Allelic Composition: Cdx1^tm1Lhn/Cdx1^tm1Lhn
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

fusion of atlas and occipital bones ( J:86514 )

• fusions occur between the anterior arch of the atlas and the basioccipital bone in about 25 % of the mice

skeleton

fusion of atlas and occipital bones ( J:86514 )

• fusions occur between the anterior arch of the atlas and the basioccipital bone in about 25 % of the mice

rib fusion ( J:86514 )

• a fused rib occurred on vertebrae 8 in one mouse out of a group of 17

cervical vertebral transformation ( J:86514 )

• 90% of mice exhibit possible transformation of the C2 vertebrae with broader C1 neural arches and/or a short cartilaginous ectopic anterior arch of the atlas on C2

Genotype
MGI:3817887

ht2

• Allelic Composition: Cdx1^tm1Lhn/Cdx1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

skeleton

abnormal basioccipital bone morphology ( J:86514 )

• a small posterior extension of the basioccipital bone occurs in 12% of mice

cervical vertebral transformation ( J:86514 )

• 12 % of mice exhibit possible transformation of the C2 vertebrae with slightly narrower C1 neural arches and/or a short cartilaginous ectopic anterior arch of the atlas on C2

craniofacial

abnormal basioccipital bone morphology ( J:86514 )

• a small posterior extension of the basioccipital bone occurs in 12% of mice

Genotype
MGI:3817893

ht3

• Allelic Composition: Cdx1^tm1Lhn/Cdx1^tm1Pgr
• Genetic Background: involves: 129 * C57BL/6

skeleton

rib fusion ( J:86514 )

• a fused rib occurred on vertebrae 8 in one mouse out of a group of 15

abnormal ventral tubercle of atlas morphology ( J:86514 )

• 33% of mice have anterior tubercles that have shifted posteriorly to the seventh cervical vertebrae

cervical vertebral transformation ( J:86514 )

• 33% of mice exhibit possible transformation of the C2 vertebrae with slightly narrower C1 neural arches and/or a short cartilaginous ectopic anterior arch of the atlas on C2

abnormal vertebral arch morphology ( J:86514 )

• 33% of mice have thick neural arches in the vertebrae

abnormal vertebral spinous process morphology ( J:86514 )

• 20% of mice have posterior spinous processes on V10 and sometimes V9

fusion of vertebral arches ( J:86514 )

• 33% of mice have neural arch fusions of V1 to V4

Genotype
MGI:3817900

cx4

• Allelic Composition: Cdx1^tm1Lhn/Cdx1⁺; Rarg^tm1Ipc/Rarg^tm1Ipc
• Genetic Background: involves: 129 * C57BL/6

skeleton

cervical vertebral transformation ( J:86514 )

• 33% of mice exhibit possible transformation of the C2 vertebrae with slightly narrower C1 neural arches and/or a short cartilaginous ectopic anterior arch of the atlas on C2

abnormal vertebral arch morphology ( J:86514 )

• 11% of mice have thick neural arches in the vertebrae

fusion of vertebral arches ( J:86514 )

• 11% of mice have neural arch fusions of V1 to V4

Genotype
MGI:3817901

cx5

• Allelic Composition: Cdx1^tm1Lhn/Cdx1^tm1Lhn; Rarg^tm1Ipc/Rarg^tm1Ipc
• Genetic Background: involves: 129 * C57BL/6

skeleton

cervical vertebral transformation ( J:86514 )

• 38% of mice exhibit possible transformation of the C2 vertebrae with slightly narrower C1 neural arches and/or a short cartilaginous ectopic anterior arch of the atlas on C2

abnormal vertebral arch morphology ( J:86514 )

• 25% of mice have thick neural arches in the vertebrae

abnormal vertebral spinous process morphology ( J:86514 )

• 19% of mice have posterior spinous processes on V10 and sometimes V9

fusion of vertebral arches ( J:86514 )

• 31% of mice have neural arch fusions of V1 to V4

Genotype
MGI:3817902

cx6

• Allelic Composition: Cdx1^tm1Lhn/Cdx1^tm1Lhn; Rarg^tm1Ipc/Rarg⁺
• Genetic Background: involves: 129 * C57BL/6

skeleton

abnormal ventral tubercle of atlas morphology ( J:86514 )

• 9% of mice have anterior tubercles that have shifted posteriorly to the seventh cervical vertebrae

cervical vertebral transformation ( J:86514 )

• 45% of mice exhibit possible transformation of the C2 vertebrae with slightly narrower C1 neural arches and/or a short cartilaginous ectopic anterior arch of the atlas on C2

abnormal vertebral arch morphology ( J:86514 )

• 36% of mice have thick neural arches in the vertebrae

abnormal vertebral spinous process morphology ( J:86514 )

• 27% of mice have posterior spinous processes on V10 and sometimes V9

fusion of vertebral arches ( J:86514 )

• 73% of mice have neural arch fusions of V1 to V4