Phenotypes associated with this allele

• Allele Symbol: Atoh7^{tm1(Neurod1)Whk}
• Allele Name: targeted mutation 1, William H Klein
• Allele ID: MGI:3817875
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Atoh7^tm1(Neurod1)Whk/Atoh7^tm2(Neurod4)Whk	involves: 129S6/SvEvTac * C57BL/6	MGI:3817913
ht2	Atoh7^tm1Gan/Atoh7^tm1(Neurod1)Whk	involves: 129S6/SvEvTac * C57BL/6	MGI:3817915

Genotype
MGI:3817913

ht1

• Allelic Composition: Atoh7^{tm1(Neurod1)Whk}/Atoh7^{tm2(Neurod4)Whk}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:141248 )

N • mice exhibit normal numbers of bipolar, Muller glial and amacrine cells

increased retina apoptosis ( J:141248 )

• from E11.5 to E16.5, retinal apoptosis is increased compared to in wild-type mice

increased retina photoreceptor cell number ( J:141248 )

• the number of opsin+ photoreceptors is increased by 20% compared to in wild-type mice

abnormal optic nerve morphology ( J:141248 )

• at P30 to P40, one-third of retinas exhibit greater numbers and higher density of retinal ganglion cell axon bundles compared to in Atoh7^tm1Gan homozygotes with the majority correctly orientated towards the optic disk

optic nerve hypoplasia ( J:141248 )

• mice exhibit severe optic nerve hypoplasia

• at 4 to 5 weeks of age, optic nerve diameters are 50% to 60% of wild-type with substantial restoration of optic nerves

nervous system

increased retina photoreceptor cell number ( J:141248 )

• the number of opsin+ photoreceptors is increased by 20% compared to in wild-type mice

abnormal optic nerve morphology ( J:141248 )

• at P30 to P40, one-third of retinas exhibit greater numbers and higher density of retinal ganglion cell axon bundles compared to in Atoh7^tm1Gan homozygotes with the majority correctly orientated towards the optic disk

optic nerve hypoplasia ( J:141248 )

• mice exhibit severe optic nerve hypoplasia

• at 4 to 5 weeks of age, optic nerve diameters are 50% to 60% of wild-type with substantial restoration of optic nerves

cellular

increased retina apoptosis ( J:141248 )

• from E11.5 to E16.5, retinal apoptosis is increased compared to in wild-type mice

Genotype
MGI:3817915

ht2

• Allelic Composition: Atoh7^tm1Gan/Atoh7^{tm1(Neurod1)Whk}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

vision/eye

increased retina apoptosis ( J:141248 )

• from E11.5 to E16.5, retinal apoptosis is increased compared to in wild-type mice

decreased retina ganglion cell number ( J:141248 )

• based of expression of retinal ganglion cell (RGC) markers at E13.5, the number of RGCs is 40% of wild-type but increases by E14.5 likely due to delayed RGC differentiation

abnormal optic nerve morphology ( J:141248 )

• at P30 to P40, two-thirds of retinas exhibit greater numbers and higher density of retinal ganglion cell axon bundles compared to in Atoh7^tm1Gan homozygotes with the majority correctly orientated towards the optic disk

optic nerve hypoplasia ( J:141248 )

• mice exhibit severe optic nerve hypoplasia

• at 4 to 5 weeks of age, optic nerve diameters are 50% to 60% of wild-type with substantial restoration of optic nerves

nervous system

decreased retina ganglion cell number ( J:141248 )

• based of expression of retinal ganglion cell (RGC) markers at E13.5, the number of RGCs is 40% of wild-type but increases by E14.5 likely due to delayed RGC differentiation

abnormal optic nerve morphology ( J:141248 )

• at P30 to P40, two-thirds of retinas exhibit greater numbers and higher density of retinal ganglion cell axon bundles compared to in Atoh7^tm1Gan homozygotes with the majority correctly orientated towards the optic disk

optic nerve hypoplasia ( J:141248 )

• mice exhibit severe optic nerve hypoplasia

• at 4 to 5 weeks of age, optic nerve diameters are 50% to 60% of wild-type with substantial restoration of optic nerves

cellular

increased retina apoptosis ( J:141248 )

• from E11.5 to E16.5, retinal apoptosis is increased compared to in wild-type mice