Phenotypes associated with this allele

• Allele Symbol: Eif6^tm1Sbif
• Allele Name: targeted mutation 1, Stefano Biffo
• Allele ID: MGI:3817934
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eif6^tm1Sbif/Eif6^tm1Sbif	involves: 129 * C57BL/6	MGI:3817961
ht2	Eif6^tm1Sbif/Eif6^+	involves: 129 * C57BL/6	MGI:3817962

Genotype
MGI:3817961

hm1

• Allelic Composition: Eif6^tm1Sbif/Eif6^tm1Sbif
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:141257 )

• no embryos at detected at E3.5

Genotype
MGI:3817962

ht2

• Allelic Composition: Eif6^tm1Sbif/Eif6⁺
• Genetic Background: involves: 129 * C57BL/6

cellular

abnormal cell physiology ( J:141257 )

• mouse embryonic fibroblasts exhibit a defect in initiating translation and fail to exhibit increased methionine incorporation following insulin stimulation unlike wild-type cells

abnormal mitosis ( J:141257 )

• following synchronization, mouse embryonic fibroblasts enter S phase 18 hours after serum addition compared to wild-type cells that enter S phase after 12 hours

liver/biliary system

decreased liver weight ( J:141257 )

liver hypoplasia ( J:141257 )

• hepatocytes exhibit reduced proliferation compared to in wild-type mice

abnormal hepatocyte physiology ( J:141257 )

• hepatocytes exhibit a defect in initiating translation and fail to exhibit increased methionine incorporation following insulin stimulation unlike wild-type cells

adipose tissue

decreased total body fat amount ( J:141257 )

• mice exhibit decreased retroperitoneal and inguinal adipose tissue weight compared to wild-type mice

abnormal fat cell morphology ( J:141257 )

• mice exhibit adipocyte hypoplasia

• however, lipid content is normal

growth/size/body

decreased body weight ( J:141257 )

• at 3 months of age, mice weight less than wild-type mice despite equivalent head to anus length