Phenotypes associated with this allele

• Allele Symbol: Lilrb4a^tm1Ttk
• Allele Name: targeted mutation 1, Toshiyuki Takai
• Allele ID: MGI:3818260
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lilrb4a^tm1Ttk/Lilrb4a^tm1Ttk	B6.129X1-Lilrb4a^tm1Ttk	MGI:3818261

Genotype
MGI:3818261

hm1

• Allelic Composition: Lilrb4a^tm1Ttk/Lilrb4a^tm1Ttk
• Genetic Background: B6.129X1-Lilrb4a^tm1Ttk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal dendritic cell antigen presentation ( J:141234 )

• bone marrow derived dendritic cells (BMDC) have an augmented ability to present antigen in vitro to both CD4⁺ and CD8⁺ T cells

• co-culturing of OVA-specific wild-type T cells and mutant BMDCs leads to increased proliferation and IL-2 secretion by the T cells

• similar results occur with BMDC stimulation of allogenic T cells

• these enhanced responses are dependent on direct cell-to-cell contact

increased susceptibility to graft versus host disease ( J:141234 )

• mutant mice that are sub-lethally irradiated and then receive allogenic splenocytes all die within 10 days compared to wild-type recipients where half the group live past 20 days after allogenic splenocyte infusion

• T cells isolated from these mice produce 2-3 fold more IFN-gamma when stimulated by allogenic cells in vitro compared to controls