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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Scn11atm1Mdba
targeted mutation 1, Mark Baker
MGI:3818305
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Scn11atm1Mdba/Scn11atm1Mdba involves: C57BL/6 MGI:3818308
hm2
 		Scn11atm1Mdba/Scn11atm1Mdba Not Specified MGI:5558030
ht3
 		Scn11atm1Mdba/Scn11atm1.1Ikth involves: 129 * BALB/c * C57BL/6 MGI:5558031


Genotype
MGI:3818308
hm1
Allelic
Composition		 Scn11atm1Mdba/Scn11atm1Mdba
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn11atm1Mdba mutation (0 available); any Scn11a mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system electrophysiology ( J:141209 )
• small diameter (less than 25 um) sensory neurons lack the persistent tetrodotoxin-resistant sodium current and cannot be stimulate to up-regulated the current by intracellular dialysis of GTP-gamma-S
• however, over-expression of the human SCN11A can restore the current




Genotype
MGI:5558030
hm2
Allelic
Composition		 Scn11atm1Mdba/Scn11atm1Mdba
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn11atm1Mdba mutation (0 available); any Scn11a mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system electrophysiology ( J:206848 )
• dorsal ganglion neurons exhibit a shifted resting membrane potential indicating active channels under resting conditions compared with wild-type cell
abnormal action potential ( J:206848 )
• increased firing threshold
• however, other action-potential characteristics are normal




Genotype
MGI:5558031
ht3
Allelic
Composition		 Scn11atm1Mdba/Scn11atm1.1Ikth
Genetic
Background		 involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn11atm1.1Ikth mutation (0 available); any Scn11a mutation (88 available)
Scn11atm1Mdba mutation (0 available); any Scn11a mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system electrophysiology ( J:206848 )
• diminished peak current densities at depolarized voltage
abnormal channel response ( J:206848 )
• channel inactivation is more pronounced than in wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory