All Phenotypes Cdk1<tm1(Cdk2)Kald> MGI Mouse

absent oocytes ( J:141249 )

• oocytes fail to develop in the atrophied ovaries of these mice

increased male germ cell apoptosis ( J:141249 )

• there is extensive apoptosis of male germ cells in 20-day old males

abnormal female reproductive system morphology ( J:141249 )

absent ovarian follicles ( J:141249 )

• no follicles are observed in the ovaries of 90-day old mice

small ovary ( J:141249 )

• ovaries of adult female mice are only half the size of controls

abnormal spermatogenesis ( J:141249 )

abnormal spermatid morphology ( J:141249 )

• round spermatids are absent in the testis of 20-day old males

abnormal spermatocyte morphology ( J:141249 )

• spermatocyte numbers are depleted in the testes of 3-month old mice

• there is an increase in the number of apoptotic spermatocytes in the testes of 10-day old mice

abnormal male meiosis ( J:141249 )

• a greater number of spermatocytes reach the pachytene stage of meiosis than controls

abnormal male reproductive system morphology ( J:141249 )

small seminiferous tubules ( J:141249 )

• the seminiferous tubules are much smaller in 3-month old males

small testis ( J:141249 )

• testis are 20-30% smaller than controls at twenty days of age

• testis of adult males are only half the size of controls

infertility ( J:141249 )

• both male and female mice are sterile

female infertility ( J:141249 )

male infertility ( J:141249 )