Phenotypes associated with this allele

• Allele Symbol: Ryr2^tm1Hhv
• Allele Name: targeted mutation 1, Hector H Valdivia
• Allele ID: MGI:3818448
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ryr2^tm1Hhv/Ryr2^tm1Hhv	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:3818452

Genotype
MGI:3818452

hm1

• Allelic Composition: Ryr2^tm1Hhv/Ryr2^tm1Hhv
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:141342 )

N • there is a trend to cardioprotection in these mice when cardiac stress is induced by banding but results do not reach significant values

N • the ratio of left ventricular mass/body-weight after banding increased to a greater extent in WT (82%) than in mutant (61%) mice

N • there was also a trend towards less systolic dysfunction caused by banding with less drop in a functional index (0.77 in wild-type versus 0.85 in mutants) and in stroke volume (25.8 microliters in wild-type versus 34.1 microliters in mutant mice)

abnormal myocardial fiber morphology ( J:141342 )

• a significantly slower time constant of decay for calcium transients is observed at 1 and 2 Hz in cardiomyocytes though this does not affect contractability of the muscle cells

muscle

abnormal myocardial fiber morphology ( J:141342 )

• a significantly slower time constant of decay for calcium transients is observed at 1 and 2 Hz in cardiomyocytes though this does not affect contractability of the muscle cells