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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igf1rtm1Jcbr
targeted mutation 1, Jens C Bruning
MGI:3818453
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Igf1rtm1Jcbr/Igf1rtm1Jcbr
Ndor1Tg(UBC-cre/ERT2)1Ejb/0 		B6.Cg-Ndor1Tg(UBC-cre/ERT2)1Ejb Igf1rtm1Jcbr MGI:5904250
cn2
 		Igf1rtm1Jcbr/Igf1rtm1Jcbr
Ndor1Tg(UBC-cre/ERT2)1Ejb/0 		involves: 129S/SvEv * C57BL/6 MGI:5779542
cn3
 		Igf1rtm1Jcbr/Igf1rtm1Jcbr
Tg(Scgb1a1-cre)1Tauc/0 		involves: C57BL/6 MGI:5904182
cn4
 		Igf1rtm1Jcbr/Igf1rtm1Jcbr
Tg(Nkx2-1-cre)2Sand/0 		involves: C57BL/6 MGI:5904181
cn5
 		Igf1rtm1Jcbr/Igf1rtm1Jcbr
Tg(Fabp4-cre)1Abel/? 		involves: C57BL/6 * FVB/N MGI:3818455


Genotype
MGI:5904250
cn1
Allelic
Composition		 Igf1rtm1Jcbr/Igf1rtm1Jcbr
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic
Background		 B6.Cg-Ndor1Tg(UBC-cre/ERT2)1Ejb Igf1rtm1Jcbr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1Jcbr mutation (0 available); any Igf1r mutation (88 available)
Ndor1Tg(UBC-cre/ERT2)1Ejb mutation (6 available); any Ndor1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to type I hypersensitivity reaction ( J:241924 )
• mice challenged with house dust mite extract show improved lung function, attenuated airway hyperresponsiveness and mucus secretion, decrease in blood and bronchioalveolar lavage fluid eosinophils, a decrease in lung IL13 levels and collagen levels, decrease in smooth muscle thickness and depletion of goblet cell metaplasia compared to controls

mortality/aging
abnormal susceptibility to injury induced morbidity/mortality ( J:241920 )
• tamoxifen treated mice treated with bleomycin to induce lung damage at 6 weeks of age show increased survival (79%) compared to controls (33%)

homeostasis/metabolism
decreased collagen level ( J:241924 )
• house dust mite-induced increase in airway collagen content is reduced in tamoxifen treated mice
abnormal susceptibility to injury induced morbidity/mortality ( J:241920 )
• tamoxifen treated mice treated with bleomycin to induce lung damage at 6 weeks of age show increased survival (79%) compared to controls (33%)
decreased susceptibility to injury ( J:241920 )
• tamoxifen treated mice show protection against lung vascular fragility and permeability, reduced inflammatory cell presence in bronchioalveolar lavage fluid, reduced proliferation in lung perivascular areas and the alveolar parenchyma, reduced alveolar damage, and attenuation of acute lung inflammation and bone marrow neutrophilopoiesis after bleomycin-induced lung damage

respiratory system
decreased respiratory mucosa goblet cell number ( J:241924 )
• house dust mite-induced goblet cell hyperplasia is reduced in tamoxifen treated mice
decreased airway responsiveness ( J:241924 )
• house dust mite-induced airway hyperresponsiveness is attenuated in tamoxifen treated mice




Genotype
MGI:5779542
cn2
Allelic
Composition		 Igf1rtm1Jcbr/Igf1rtm1Jcbr
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1Jcbr mutation (0 available); any Igf1r mutation (88 available)
Ndor1Tg(UBC-cre/ERT2)1Ejb mutation (6 available); any Ndor1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:221618 )
N
• tamoxifen-treated mice exhibit normal testicular peritubular capsule and Leydig cells
small seminiferous tubules ( J:221618 )
• in tamoxifen-treated mice
decreased testis weight ( J:221618 )
• in mice treated with tamoxifen at 4 weeks
abnormal spermatogenesis ( J:221618 )
• in tamoxifen-treated mice
azoospermia ( J:221618 )
• in tamoxifen-treated mice
oligozoospermia ( J:221618 )
• seminiferous tubules in tamoxifen-treated mice are severely depleted of germ cells, including spermatogonia, spermatocytes, and spermatids

growth/size/body
decreased body weight ( J:221618 )
• beginning after a week tamoxifen treatment starting at 4 weeks
postnatal growth retardation ( J:221618 )
• in mice treated with tamoxifen at 4 weeks

respiratory system
abnormal bronchiole epithelium morphology ( J:221618 )
• distal bronchiolar epithelium in tamoxifen-treated mice is flatter with frequent interruptions and reduced cell height, proportion of cells with apical regions extruding into the bronchiolar lumen and nuclear density compared with control cells
abnormal pulmonary alveolar parenchyma morphology ( J:221618 )
• higher cellular density in tamoxifen-treated mice without a change in apoptosis rates

liver/biliary system
increased hepatocyte proliferation ( J:221618 )
• 2-3 times higher in tamoxifen-treated mice without an affect in liver cellularity density or changes in apoptosis rates compared with wild-type mice

cellular
azoospermia ( J:221618 )
• in tamoxifen-treated mice
oligozoospermia ( J:221618 )
• seminiferous tubules in tamoxifen-treated mice are severely depleted of germ cells, including spermatogonia, spermatocytes, and spermatids
increased hepatocyte proliferation ( J:221618 )
• 2-3 times higher in tamoxifen-treated mice without an affect in liver cellularity density or changes in apoptosis rates compared with wild-type mice

endocrine/exocrine glands
small seminiferous tubules ( J:221618 )
• in tamoxifen-treated mice
decreased testis weight ( J:221618 )
• in mice treated with tamoxifen at 4 weeks




Genotype
MGI:5904182
cn3
Allelic
Composition		 Igf1rtm1Jcbr/Igf1rtm1Jcbr
Tg(Scgb1a1-cre)1Tauc/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1Jcbr mutation (0 available); any Igf1r mutation (88 available)
Tg(Scgb1a1-cre)1Tauc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal response to injury ( J:241923 )
• mice show a mild delay in recovery of terminal bronchiolar epithelium after naphthalene treatment to induce club cell damage, with a delay in the differentiation/regeneration of club and ciliated cells

respiratory system
abnormal bronchiole epithelium morphology ( J:241923 )
• smaller epithelial cell size in some terminal bronchioles
• lower proportion of Scgb1a1+ club cells in some terminal bronchioles




Genotype
MGI:5904181
cn4
Allelic
Composition		 Igf1rtm1Jcbr/Igf1rtm1Jcbr
Tg(Nkx2-1-cre)2Sand/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1Jcbr mutation (0 available); any Igf1r mutation (88 available)
Tg(Nkx2-1-cre)2Sand mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:241923 )
• mice are significantly overweight after puberty

homeostasis/metabolism
abnormal response to injury ( J:241923 )
• mice show a delay in recovery of terminal bronchiolar epithelium after naphthalene treatment to induce club cell damage, with a delay in the differentiation/regeneration of club and ciliated cells
• mice show increased proliferation of bronchiolar epithelial cells during repair of the epithelium after naphthalene treatment to induce damage and club cell ablation

respiratory system
abnormal bronchiole epithelium morphology ( J:241923 )
• smaller epithelial cell size in terminal bronchioles
• lower proportion of Scgb1a1+ club cells
• distal bronchiolar epithelium shows morphological changes including lower cell density, flatter cells with elongated nuclei and frequent interruptions of normal columnar organization
• however, no gross morphological alterations are seen in AEC2 cells or in the surrounding alveolar parenchyma
• proliferation of airway club cells is enhanced in terminal bronchial epithelium




Genotype
MGI:3818455
cn5
Allelic
Composition		 Igf1rtm1Jcbr/Igf1rtm1Jcbr
Tg(Fabp4-cre)1Abel/?
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1Jcbr mutation (0 available); any Igf1r mutation (88 available)
Tg(Fabp4-cre)1Abel mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased heart weight ( J:141321 )
• disproportionately increased at 24 weeks
increased body weight ( J:141321 )
• both males and females have gained more weight than controls by 10 weeks of age
• daily food intake normal
increased body length ( J:141321 )
• significantly increased naso-anal length by 24-32 weeks of age
increased liver weight ( J:141321 )
• disproportionately increased at 24 weeks

adipose tissue
increased total body fat amount ( J:141321 )
• disproportionately increased in weight at 24 weeks
abnormal fat cell morphology ( J:141321 )
• increased number and diameter of adipocytes
abnormal gonadal fat pad morphology ( J:141321 )
• adipocyte abnormalities particularly evident in epigonadal fat

liver/biliary system
increased liver weight ( J:141321 )
• disproportionately increased at 24 weeks

cardiovascular system
increased heart weight ( J:141321 )
• disproportionately increased at 24 weeks

nervous system
decreased brain size ( J:141321 )
• relative brain weight is significantly reduced at 24 weeks

homeostasis/metabolism
increased circulating glucose level ( J:141321 )
• fasted blood glucose significantly increased at 12 weeks but not 24 weeks of age
• fed blood glucose levels in males also increased at 12 weeks
increased insulin sensitivity ( J:141321 )
• of isolated adipocytes
decreased adiponectin level ( J:141321 )
• significantly lower at 12 weeks




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory