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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Aicdatm4Mnz
targeted mutation 4, Michel C Nussenzweig
MGI:3818467
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Aicdatm4Mnz/Aicda+ involves: C57BL/6 * CBA MGI:3818479
ht2
 		Aicdatm1Hon/Aicdatm4Mnz involves: C57BL/6 * CBA MGI:3818481


Genotype
MGI:3818479
ht1
Allelic
Composition		 Aicdatm4Mnz/Aicda+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm4Mnz mutation (0 available); any Aicda mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:141427 )
• B cells show 87% the level of class switch recombination (CSR) to IgG1 that occurs with wild-type controls when cultured in the presence of LPS and IL-4
• when stimulated with LPS or LPS and anti-dextran, B cells show 71 or 52% the level of CSR to IgG3 of wild-type controls
abnormal somatic hypermutation frequency ( J:141427 )
• somatic hypermutation by germinal center B cells is 45% of what occurs in wild-type
• somatic hypermutation by peyer's patch B cells is 40% of what occurs in wild-type

hematopoietic system
abnormal class switch recombination ( J:141427 )
• B cells show 87% the level of class switch recombination (CSR) to IgG1 that occurs with wild-type controls when cultured in the presence of LPS and IL-4
• when stimulated with LPS or LPS and anti-dextran, B cells show 71 or 52% the level of CSR to IgG3 of wild-type controls
abnormal somatic hypermutation frequency ( J:141427 )
• somatic hypermutation by germinal center B cells is 45% of what occurs in wild-type
• somatic hypermutation by peyer's patch B cells is 40% of what occurs in wild-type




Genotype
MGI:3818481
ht2
Allelic
Composition		 Aicdatm1Hon/Aicdatm4Mnz
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Aicdatm4Mnz mutation (0 available); any Aicda mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:141427 )
• B cells show 45% the level of class switch recombination to IgG1 that occurs with wild-type controls when cultured in the presence of LPS and IL-4
abnormal somatic hypermutation frequency ( J:141427 )
• the somatic mutation rate of the upstream region of the S-mu switch repeats is 85% the rate that occurs in stimulated wild-type B cells
• somatic hypermutation by germinal center and Peyer's patch B cells does not exceed basal mutation rates

hematopoietic system
abnormal class switch recombination ( J:141427 )
• B cells show 45% the level of class switch recombination to IgG1 that occurs with wild-type controls when cultured in the presence of LPS and IL-4
abnormal somatic hypermutation frequency ( J:141427 )
• the somatic mutation rate of the upstream region of the S-mu switch repeats is 85% the rate that occurs in stimulated wild-type B cells
• somatic hypermutation by germinal center and Peyer's patch B cells does not exceed basal mutation rates




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory