Analysis Tools|
Allele Symbol Allele Name Allele ID |
Zbtb7btm2Litt targeted mutation 2, Dan R Littman MGI:3818473 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• CD4+ T cells are almost completely absent
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• CD4+ T cells are almost completely absent
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• there is about a 30-fold reduction in the number of single-positive CD4+ cells among mature thymocytes
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• there is about a 30-fold reduction in the number of single-positive CD4+ cells among mature thymocytes
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• the number of HSAhiCD69+ and
HSAhi TCRbetahi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice
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• absolute numbers of CD4+ single positive mature thymocytes are reduced by 5 to 10 fold compared to controls
• the percentage of CD4+ T cells in peripheral lymph nodes is reduced by almost 20-fold
|
|
• the number of HSAhiCD69+ and
HSAhi TCRbetahi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice
|
|
• absolute numbers of CD4+ single positive mature thymocytes are reduced by 5 to 10 fold compared to controls
• the percentage of CD4+ T cells in peripheral lymph nodes is reduced by almost 20-fold
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• the number of HSAhiCD69+ and
HSAhi TCRbetahi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice
|
|
• absolute numbers of CD4+ single positive mature thymocytes are reduced by 5 to 10 fold compared to controls
• however, the percentage of CD4+ T cells in peripheral lymph nodes is only slightly reduced
|
|
• the number of HSAhiCD69+ and
HSAhi TCRbetahi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice
|
|
• absolute numbers of CD4+ single positive mature thymocytes are reduced by 5 to 10 fold compared to controls
• however, the percentage of CD4+ T cells in peripheral lymph nodes is only slightly reduced
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• the number of HSAhiCD69+ and
HSAhi TCRbetahi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice
|
|
• absolute numbers of CD4+ single positive mature thymocytes are reduced between 5-10 fold compared to controls
• however, the percentage of CD4+ T cells in peripheral lymph nodes is only slightly reduced
|
|
• the number of HSAhiCD69+ and
HSAhi TCRbetahi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice
|
|
• absolute numbers of CD4+ single positive mature thymocytes are reduced between 5-10 fold compared to controls
• however, the percentage of CD4+ T cells in peripheral lymph nodes is only slightly reduced
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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