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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Runx3tm1Litt
targeted mutation 1, Dan R Littman
MGI:3818488
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Runx3tm1Litt/Runx3tm1Litt involves: 129P2/OlaHsd MGI:3821704


Genotype
MGI:3821704
hm1
Allelic
Composition		 Runx3tm1Litt/Runx3tm1Litt
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx3tm1Litt mutation (1 available); any Runx3 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD8-positive, alpha-beta T cell differentiation ( J:141144 )
• peripheral CD8+ T cells also express variable amounts of CD4
• 1.6% of CD8+ T cells co-express CD103 compared to 12% in controls
abnormal double-positive T cell morphology ( J:141144 )
• peripheral CD8+ T cells also express variable amounts of CD4

hematopoietic system
abnormal CD8-positive, alpha-beta T cell differentiation ( J:141144 )
• peripheral CD8+ T cells also express variable amounts of CD4
• 1.6% of CD8+ T cells co-express CD103 compared to 12% in controls
abnormal double-positive T cell morphology ( J:141144 )
• peripheral CD8+ T cells also express variable amounts of CD4




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory