All Phenotypes Coro1a<koy> MGI Mouse

immune system

• the percentage of mature (CD69^loCD62L^hi) single-positive thymocytes is decreased in these mice

• CD4⁺ T cell numbers in the periphery are significantly decreased about 5-fold

• CD8⁺ T cell numbers in the periphery are significantly decreased about 5-fold

• in vitro transwell assays demonstrate migration defects in thymic CD4⁺ T cells' response to sphingosine 1-phosphate, CCL21, and CXCL12

• similar defects are observed in the migratory response of CD4⁺CD8⁺ T cells to CXCL12 and of splenic CD4⁺ T cells to CCL21

hematopoietic system

decreased thymocyte number ( J:141431 )

• the percentage of mature (CD69^loCD62L^hi) single-positive thymocytes is decreased in these mice

• CD4⁺ T cell numbers in the periphery are significantly decreased about 5-fold

• CD8⁺ T cell numbers in the periphery are significantly decreased about 5-fold

abnormal T cell physiology ( J:141431 )

• in vitro transwell assays demonstrate migration defects in thymic CD4⁺ T cells' response to sphingosine 1-phosphate, CCL21, and CXCL12

• similar defects are observed in the migratory response of CD4⁺CD8⁺ T cells to CXCL12 and of splenic CD4⁺ T cells to CCL21

endocrine/exocrine glands

decreased thymocyte number ( J:141431 )

• the percentage of mature (CD69^loCD62L^hi) single-positive thymocytes is decreased in these mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive		DOID:0090014	OMIM:608971	J:141431

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24