Phenotypes associated with this allele

• Allele Symbol: Supv3l1^tm1Jkl
• Allele Name: targeted mutation 1, Jan Klysik
• Allele ID: MGI:3818518
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Supv3l1^tm1Jkl/Supv3l1^tm1Jkl	involves: 129S7/SvEvBrd * C57BL/6	MGI:3818520
ht2	Supv3l1^tm1Jkl/Supv3l1^+	involves: 129S7/SvEvBrd * C57BL/6	MGI:3818519

Genotype
MGI:3818520

hm1

• Allelic Composition: Supv3l1^tm1Jkl/Supv3l1^tm1Jkl
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:141467 )

• fewer than expected mice are present at E9.5 and all mice are dead by E12.5

embryo

abnormal embryo development ( J:141467 )

• at E10.5, the only surviving mouse exhibited severe morphological abnormalities

craniofacial

abnormal craniofacial development ( J:141467 )

• at E10.5, the only surviving mouse exhibited highly disorganized craniofacial area tissues

Genotype
MGI:3818519

ht2

• Allelic Composition: Supv3l1^tm1Jkl/Supv3l1⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

mortality/aging

decreased survivor rate ( J:141467 )

• fewer than expected mice are present at E12.5 but surviving mice are indistinguishable from wild-type mice

embryonic lethality during organogenesis, incomplete penetrance ( J:141467 )

• fewer than expected mice are present at E12.5 but surviving mice are indistinguishable from wild-type mice

reproductive system

transmission ratio distortion ( J:141467 )

• transmission rates deviates from Mendelian rates by 35%