Phenotypes associated with this allele

• Allele Symbol: Senp2^{Gt(AN0727)Wtsi}
• Allele Name: gene trap AN0727, Wellcome Trust Sanger Institute
• Allele ID: MGI:3818535
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Senp2^Gt(AN0727)Wtsi/Senp2^Gt(AN0727)Wtsi	involves: 129P2/OlaHsd	MGI:3818544

Genotype
MGI:3818544

hm1

• Allelic Composition: Senp2^{Gt(AN0727)Wtsi}/Senp2^{Gt(AN0727)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:162938 )

• mice die between E9.5 and E13.5

cardiovascular system

thin myocardium ( J:162938 )

abnormal cardiac epithelial to mesenchymal transition ( J:162938 )

• the atrioventricular endocardial cushions contain few mesenchymal cells

abnormal heart development ( J:162938 )

• at E10.5, mice exhibit smaller cardiac chambers than wild-type mice

• at E10.5, hearts exhibit reduced cellular proliferation compared with wild-type mice

• however, cardiac apoptosis is normal

abnormal atrioventricular cushion morphology ( J:162938 )

• the atrioventricular endocardial cushions are thinner than in wild-type mice

pericardial effusion ( J:162938 )

homeostasis/metabolism

pericardial effusion ( J:162938 )

muscle

thin myocardium ( J:162938 )