Phenotypes associated with this allele

• Allele Symbol: Retnlb^tm1Mer
• Allele Name: targeted mutation 1, Marc E Rothenberg
• Allele ID: MGI:3818561
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Retnlb^tm1Mer/Retnlb^tm1Mer	involves: 129S1/Sv	MGI:3818573
hm2	Retnlb^tm1Mer/Retnlb^tm1Mer	involves: 129S1/Sv * C57BL/6	MGI:3818571

Genotype
MGI:3818573

hm1

• Allelic Composition: Retnlb^tm1Mer/Retnlb^tm1Mer
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased IgG1 level ( J:141446 )

• following infection with Trichuris, mice exhibit an elevation in Trichuris-specific IgG1 levels compared to in similarly treated wild-type mice

decreased IgG2a level ( J:141446 )

• following infection with Trichuris, mice exhibit a reduction in Trichuris-specific IgG2a compared to in similarly treated wild-type mice

decreased interferon-gamma secretion ( J:141446 )

• following infection with Trichuris, mice exhibit a 4-fold reduction in IFN-gamma+ CD4+ T cells compared to in similarly treated wild-type mice

• following antigen specific restimulation, mesenteric lymph node cells secrete less IFN-gamma and TNF-alpha that wild-type cells

decreased tumor necrosis factor secretion ( J:141446 )

• following infection with Trichuris, mice exhibit a 2-fold reduction in TNF-alpha+ CD4+ T cells compared to in similarly treated wild-type mice

• following antigen specific restimulation, mesenteric lymph node cellss secrete less IFN-gamma and TNF-alpha that wild-type cells

decreased susceptibility to parasitic infection ( J:141446 )

• following infection with Trichuris, mice exhibit a 2-fold reduction in TNF-alpha+ CD4+ T cells and a 4-fold reduction in IFN-gamma+ CD4+ T cells compared to in similarly treated wild-type mice

• following infection with Trichuris, mice exhibit a reduction in Trichuris-specific IgG2a but an elevation in Trichuris-specific IgG1 levels compared to in similarly treated wild-type mice

• following infection with Trichuris, mice exhibit do not exhibit intestinal inflammation as in similarly treated wild-type mice

• however, Trichuris infection induces intestinal crypt elongation and mucus production by goblet cells as in wild-type mice

• mice are resistant to chronis Trichuris infection and severe intestinal inflammation

hematopoietic system

increased IgG1 level ( J:141446 )

• following infection with Trichuris, mice exhibit an elevation in Trichuris-specific IgG1 levels compared to in similarly treated wild-type mice

decreased IgG2a level ( J:141446 )

• following infection with Trichuris, mice exhibit a reduction in Trichuris-specific IgG2a compared to in similarly treated wild-type mice

Genotype
MGI:3818571

hm2

• Allelic Composition: Retnlb^tm1Mer/Retnlb^tm1Mer
• Genetic Background: involves: 129S1/Sv * C57BL/6

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:141524 )

• intestinal epithelial cell resistance is decreased compared to in wild-type mice

abnormal digestive system physiology ( J:141524 )

• intestinal permeability is increased on average 266% compared to in wild-type mice

decreased susceptibility to induced colitis ( J:141524 )

• following induction of experimental colitis with DSS, mice exhibit reduced weight loss, colonic shortening, diarrhea-rectal bleeding, submucosal damage, and mortality compared to similarly treated wild-type mice

increased susceptibility to induced colitis ( J:141524 )

• following induction of experimental colitis with TNBS, mice exhibit increased severity of disease with ulcerations of the colonic epithelium, loss of crypts and pronounced cellular infiltrate compared to in similarly-treated wild-type mice

immune system

decreased susceptibility to induced colitis ( J:141524 )

• following induction of experimental colitis with DSS, mice exhibit reduced weight loss, colonic shortening, diarrhea-rectal bleeding, submucosal damage, and mortality compared to similarly treated wild-type mice

increased susceptibility to induced colitis ( J:141524 )

• following induction of experimental colitis with TNBS, mice exhibit increased severity of disease with ulcerations of the colonic epithelium, loss of crypts and pronounced cellular infiltrate compared to in similarly-treated wild-type mice