Analysis Tools
digestive/alimentary system
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• aberrant, disorganized granules as well as decreased granule numbers are observed in these mice
• virtually all Paneth cells have lysozyme localized throughout the cell instead of being discretely packaged within vesicles
• Paneth cells also have degenerating mitochondria, loss of granules and the frequent absence of apical microvilli
• adjacent crypt lumen often contains intact Paneth granules and cytoplasm, which is a phenomenon not observed in wild-type controls
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homeostasis/metabolism
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• autophagy by the ileal epithelium and thymocytes is severely reduced in these mice
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cellular
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• autophagy by the ileal epithelium and thymocytes is severely reduced in these mice
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endocrine/exocrine glands
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• aberrant, disorganized granules as well as decreased granule numbers are observed in these mice
• virtually all Paneth cells have lysozyme localized throughout the cell instead of being discretely packaged within vesicles
• Paneth cells also have degenerating mitochondria, loss of granules and the frequent absence of apical microvilli
• adjacent crypt lumen often contains intact Paneth granules and cytoplasm, which is a phenomenon not observed in wild-type controls
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reproductive system
| N |
• when mated with wild-type males of proven fertility, females show normal fertility with no significant differences in the number of pups per litter relative to controls
• in culture, hormonally stimulated endometrial cells show normal decidualization with increased mRNA expression of the decidualization marker Prp
• in vivo, upon oil-induced artificial decidualization, stimulated uterine horns exhibit increased uterine weight, indicative of proper decidualization
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| inflammatory bowel disease 10 | DOID:0110885 |
OMIM:611081 |
J:141419 | |
