All Phenotypes Nampt<tm1Oleo> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nampt^tm1Oleo/Nampt^tm1Oleo Tg(CD2-icre)4Kio/0	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/10 * CBA/Ca	MGI:3818632
cn2	Nampt^tm1Oleo/Nampt^tm1Oleo Tg(Rho-icre)1Ck/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:6383809
cn3	Nampt^tm1Oleo/Nampt^tm1Oleo Tg(OPN1LW-cre)4Yzl/0	involves: 129P2/OlaHsd * FVB/N	MGI:6383810

Allelic Composition	Nampt^tm1Oleo/Nampt^tm1Oleo Tg(CD2-icre)4Kio/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/10 * CBA/Ca

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nampt^tm1Oleo mutation (1 available); any Nampt mutation (91 available)
Tg(CD2-icre)4Kio mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:141448 )

• thymic cell numbers are decreased 95% compared to in wild-type mice

decreased B cell number ( J:141448 )

• mice exhibit a near complete lack of peripheral B cells

decreased T cell number ( J:141448 )

• mice exhibit a near complete lack of peripheral T cells

decreased double-negative T cell number ( J:141448 )

• mice exhibit a near complete absence of double negative T cells compared to in wild-type mice

hematopoietic system

thymus hypoplasia ( J:141448 )

• thymic cell numbers are decreased 95% compared to in wild-type mice

decreased B cell number ( J:141448 )

• mice exhibit a near complete lack of peripheral B cells

decreased T cell number ( J:141448 )

• mice exhibit a near complete lack of peripheral T cells

decreased double-negative T cell number ( J:141448 )

• mice exhibit a near complete absence of double negative T cells compared to in wild-type mice

endocrine/exocrine glands

thymus hypoplasia ( J:141448 )

• thymic cell numbers are decreased 95% compared to in wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

optic nerve atrophy ( J:265592 )

• secondary with pallor by 6 weeks

abnormal retina morphology ( J:265592 )

• rounded and constricted with loss of cristae in the retinal mitochondria by 4 weeks

• cytoplasmic vacuoles containing degenerating organelles including ruptured mitochondria

abnormal photoreceptor inner segment morphology ( J:265592 )

• by 4 weeks

abnormal photoreceptor outer segment morphology ( J:265592 )

• by 4 weeks

retina photoreceptor degeneration ( J:265592 )

• by 6 weeks with massive atrophy of the neurosensory retina and vascular attenuation with pigment mottling

• however, nicotinamide mononucleotide treatment rescued regeneration

retina pigment epithelium atrophy ( J:265592 )

• by 6 weeks

thin retina outer nuclear layer ( J:265592 )

• progressive and almost completely absent by 6 weeks

decreased total retina thickness ( J:265592 )

• by 6 weeks

abnormal cone electrophysiology ( J:265592 )

• reduced b-waves amplitudes by 6 weeks of age

• reduced visual acuity by 6 weeks of age

• however, nicotinamide mononucleotide treatment rescued function

abnormal rod electrophysiology ( J:265592 )

• reduced a-waves amplitudes by 6 weeks of age

• however, nicotinamide mononucleotide treatment rescued function

cellular

abnormal mitochondrial morphology ( J:265592 )

• rounded and constricted with loss of cristae in the retinal mitochondria by 4 weeks

abnormal mitochondrial crista morphology ( J:265592 )

• loss of cristae in the retinal mitochondria by 4 weeks

nervous system

abnormal photoreceptor inner segment morphology ( J:265592 )

• by 4 weeks

abnormal photoreceptor outer segment morphology ( J:265592 )

• by 4 weeks

retina photoreceptor degeneration ( J:265592 )

• by 6 weeks with massive atrophy of the neurosensory retina and vascular attenuation with pigment mottling

• however, nicotinamide mononucleotide treatment rescued regeneration

optic nerve atrophy ( J:265592 )

• secondary with pallor by 6 weeks

pigmentation

retina pigment epithelium atrophy ( J:265592 )

• by 6 weeks

Allelic Composition	Nampt^tm1Oleo/Nampt^tm1Oleo Tg(OPN1LW-cre)4Yzl/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nampt^tm1Oleo mutation (1 available); any Nampt mutation (91 available)
Tg(OPN1LW-cre)4Yzl mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

retina cone cell degeneration ( J:265592 )

• at 3 weeks with massive atrophy of the neurosensory retina and vascular attenuation with pigment mottling

retina pigment epithelium atrophy ( J:265592 )

• at 3 weeks

abnormal cone electrophysiology ( J:265592 )

• photopic b-wave amplitude

• reduced visual acuity

• however, nicotinamide mononucleotide treatment rescued function

abnormal rod electrophysiology ( J:265592 )

• mild decline inn scotopic a- and b-wave amplitudes

• however, nicotinamide mononucleotide treatment rescued function

nervous system

retina cone cell degeneration ( J:265592 )

• at 3 weeks with massive atrophy of the neurosensory retina and vascular attenuation with pigment mottling

pigmentation

retina pigment epithelium atrophy ( J:265592 )

• at 3 weeks

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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