Analysis Tools
immune system
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• mice have moderately increased T-cell proliferation, which is significant only at a concentration of 2.5 micrograms/mL of anti-CD3 stimulation
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• mean IgA levels in serum of nave mice is reduced by more than 75% compared to controls
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• serum levels of antigen-specific IgG1 is increased after immunization with OVA + adjuvant
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• mice in a collagen-induced arthritis model have lower levels of collagen-specific antibodies in circulation than in controls
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• increased IFN-gamma production is observed in naive splenocytes stimulated with anti-CD3
• this production of IFN-gamma increases even more upon secondary stimulation
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• inguinal lymph node cells isolated from mice one week after immunization with collagen are lower on the IL-17/TNF, IL-17/IL-6, TNF/IL-6 secretion axes than controls
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• T cells polarized in vitro to a Th17 phenotype secrete less IL-10 than controls upon primary stimulation
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• T cells polarized in vitro to a Th2 phenotype secrete more IL-13 than controls upon primary and secondary stimulation
• nave T cells also have increased IL-13 secretion upon secondary stimulation
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• inguinal lymph node cells isolated from mice one week after immunization with collagen produce less IL-17 upon collagen incubation than controls
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• T cells polarized in vitro to a Th2 phenotype secrete more IL-17 than controls upon secondary stimulation
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• IL-4 secretion by naive T cells stimulated with anti-CD3 is slightly higher than controls upon primary stimulation and increased even more upon secondary stimulation
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• nave T cells have increased IL-5 secretion upon secondary stimulation
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• mice have a 21.3% decrease in the incidence of arthritis after induction with collagen injection
• onset of disease is significantly lower 22 to 33 days after challenge with collagen compared to controls
• clinical scores and disease pathology of mice develop arthritis are similar to controls
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skeleton
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• mice have a 21.3% decrease in the incidence of arthritis after induction with collagen injection
• onset of disease is significantly lower 22 to 33 days after challenge with collagen compared to controls
• clinical scores and disease pathology of mice develop arthritis are similar to controls
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hematopoietic system
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• mice have moderately increased T-cell proliferation, which is significant only at a concentration of 2.5 micrograms/mL of anti-CD3 stimulation
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• mean IgA levels in serum of nave mice is reduced by more than 75% compared to controls
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• serum levels of antigen-specific IgG1 is increased after immunization with OVA + adjuvant
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• mice in a collagen-induced arthritis model have lower levels of collagen-specific antibodies in circulation than in controls
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cellular
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• mice have moderately increased T-cell proliferation, which is significant only at a concentration of 2.5 micrograms/mL of anti-CD3 stimulation
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