Analysis Tools
reproductive system
infertility
(
J:141391
)
nervous system
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• the number of neurons undergoing apoptosis in the CA3 region is increased compared to in wild-type mice
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• at 5 weeks of age, mice exhibit a loss of pyramidal neurons in the CA3 region that progressively worsens with age unlike in wild-type mice
• however, the numbers of pyramidal cells in the CA1 region and mossy fiber attachments are normal
• pyramidal neuron loss is due to increased apoptosis of cells
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behavior/neurological
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• mice exhibit a reduced latency to entering in a dark box compared to wild-type mice in a passive avoidance test
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• mice exhibit increased time immobilized during a swim test despite normal muscle strength
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growth/size/body
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• begining at 3 weeks
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• by 8 weeks of age, mice cease to gain weight unlike wild-type mice
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cellular
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• the number of neurons undergoing apoptosis in the CA3 region is increased compared to in wild-type mice
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