cardiovascular system
N |
• no significant differences are detected in systolic blood pressure, left ventricular wall thickness, or left ventricular mass to tibial length ratio
|
• echocardiography suggests a slight increase in left ventricular dimensions
|
• isolated perfused hearts from 17 to 20 week old mice show a dramatic increase in 2-deoxyglucose uptake during insulin free perfusion compared to controls
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• echocardiography suggests a slight decrease in left ventricular fractional shortening
|
• decrease in pressure overload induced progressive hypertrophy during the early phase compared to controls
• however, in the late phase impairment of cardiac function is increased compared to controls
|
homeostasis/metabolism
N |
• unlike mice carrying TxnipHyplip1 serum levels of cholesterol and triglycerides are similar to controls
|
• decrease in pressure overload induced progressive hypertrophy during the early phase compared to controls
• however, in the late phase impairment of cardiac function is increased compared to controls
|
• in fasting mice compared to controls
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muscle
• isolated perfused hearts from 17 to 20 week old mice show a dramatic increase in 2-deoxyglucose uptake during insulin free perfusion compared to controls
|
• echocardiography suggests a slight decrease in left ventricular fractional shortening
|
cellular
• isolated perfused hearts from 17 to 20 week old mice show a dramatic increase in 2-deoxyglucose uptake during insulin free perfusion compared to controls
|