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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Txniptm1.1Rlee
targeted mutation 1.1, Richard T Lee
MGI:3818744
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Txniptm1.1Rlee/Txniptm1.1Rlee involves: 129S4/SvJae MGI:3818745


Genotype
MGI:3818745
hm1
Allelic
Composition
Txniptm1.1Rlee/Txniptm1.1Rlee
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Txniptm1.1Rlee mutation (1 available); any Txnip mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• no significant differences are detected in systolic blood pressure, left ventricular wall thickness, or left ventricular mass to tibial length ratio
• echocardiography suggests a slight increase in left ventricular dimensions
• isolated perfused hearts from 17 to 20 week old mice show a dramatic increase in 2-deoxyglucose uptake during insulin free perfusion compared to controls
• echocardiography suggests a slight decrease in left ventricular fractional shortening
• decrease in pressure overload induced progressive hypertrophy during the early phase compared to controls
• however, in the late phase impairment of cardiac function is increased compared to controls

homeostasis/metabolism
N
• unlike mice carrying TxnipHyplip1 serum levels of cholesterol and triglycerides are similar to controls
• decrease in pressure overload induced progressive hypertrophy during the early phase compared to controls
• however, in the late phase impairment of cardiac function is increased compared to controls
• in fasting mice compared to controls

muscle
• isolated perfused hearts from 17 to 20 week old mice show a dramatic increase in 2-deoxyglucose uptake during insulin free perfusion compared to controls
• echocardiography suggests a slight decrease in left ventricular fractional shortening

cellular
• isolated perfused hearts from 17 to 20 week old mice show a dramatic increase in 2-deoxyglucose uptake during insulin free perfusion compared to controls





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory