All Phenotypes Ret<tm1Giro> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ret^tm1Giro
targeted mutation 1, Giovanni Romeo
MGI:3819163

Summary

3 genotypes

Allelic Composition	Ret^tm1Giro/Ret^tm1Giro
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm1Giro mutation (0 available); any Ret mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• mice die within 24 hours of birth

nervous system

nervous system phenotype ( J:141658 )

N	• unlike in Ret^tm1Cos homozygotes, mice develop normal superior cervical ganglia

abnormal neuron differentiation ( J:141658 )

• cultures of neural crest cells destined to colonize the bowels exhibit reduced Ret+ cell expansion compared to wild-type cultures

• mice exhibit defective ganglion formation along the entire bowel and stomach ganglions are absent or rare unlike in wild-type mice

renal/urinary system

absent kidney ( J:141658 )

cellular

abnormal neuron differentiation ( J:141658 )

• cultures of neural crest cells destined to colonize the bowels exhibit reduced Ret+ cell expansion compared to wild-type cultures

Allelic Composition	Ret^tm1Giro/Ret⁺
Genetic Background	129.129P2-Ret^tm1Giro

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm1Giro mutation (0 available); any Ret mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

adrenal cortical hyperplasia ( J:141658 )

• 14% to 15% of mice exhibit adrenal gland cortical nodular regeneration or hyperplasia

abnormal thyroid gland morphology ( J:141658 )

• thyroid gland dysplasia and adenoma are observed in 12% of mice unlike in wild-type mice

• thyroid gland dysplasia and adenoma are observed in 12% of mice unlike in wild-type mice

neoplasm

• thyroid gland dysplasia and adenoma are observed in 12% of mice unlike in wild-type mice

Allelic Composition	Ret^tm1Giro/Ret⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm1Giro mutation (0 available); any Ret mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

adrenal cortical hyperplasia ( J:141658 )

• 14% to 15% of mice exhibit adrenal gland cortical nodular regeneration or hyperplasia

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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