All Phenotypes Ret<tm1Giro> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ret^tm1Giro
targeted mutation 1, Giovanni Romeo
MGI:3819163

Summary

3 genotypes

Allelic Composition	Ret^tm1Giro/Ret^tm1Giro
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm1Giro mutation (0 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• mice die within 24 hours of birth

nervous system

nervous system phenotype ( J:141658 )

N	• unlike in Ret^tm1Cos homozygotes, mice develop normal superior cervical ganglia

abnormal neuron differentiation ( J:141658 )

• cultures of neural crest cells destined to colonize the bowels exhibit reduced Ret+ cell expansion compared to wild-type cultures

• mice exhibit defective ganglion formation along the entire bowel and stomach ganglions are absent or rare unlike in wild-type mice

renal/urinary system

absent kidney ( J:141658 )

cellular

abnormal neuron differentiation ( J:141658 )

• cultures of neural crest cells destined to colonize the bowels exhibit reduced Ret+ cell expansion compared to wild-type cultures

Allelic Composition	Ret^tm1Giro/Ret⁺
Genetic Background	129.129P2-Ret^tm1Giro

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm1Giro mutation (0 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

adrenal cortical hyperplasia ( J:141658 )

• 14% to 15% of mice exhibit adrenal gland cortical nodular regeneration or hyperplasia

abnormal thyroid gland morphology ( J:141658 )

• thyroid gland dysplasia and adenoma are observed in 12% of mice unlike in wild-type mice

• thyroid gland dysplasia and adenoma are observed in 12% of mice unlike in wild-type mice

neoplasm

• thyroid gland dysplasia and adenoma are observed in 12% of mice unlike in wild-type mice

Allelic Composition	Ret^tm1Giro/Ret⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm1Giro mutation (0 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

adrenal cortical hyperplasia ( J:141658 )

• 14% to 15% of mice exhibit adrenal gland cortical nodular regeneration or hyperplasia

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24