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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Arhgef12tm1Soff
targeted mutation 1, Stefan Offermanns
MGI:3819185
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Arhgef12tm1Soff/Arhgef12tm1Soff Not Specified MGI:3819344


Genotype
MGI:3819344
hm1
Allelic
Composition		 Arhgef12tm1Soff/Arhgef12tm1Soff
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef12tm1Soff mutation (0 available); any Arhgef12 mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:141641 )
N
• despite abnormal response to vasoconstrictors, mice maintain normal basal blood pressure
decreased systemic arterial blood pressure ( J:141641 )
• mice treated with DOCA-salt do not develop hypertension as do wild-type mice
decreased vasoconstriction ( J:141641 )
• mice exhibit reduced vasocontraction in response to angiotensin II, and endothelin-1 compared to in similarly treated wild-type mice

muscle
decreased vasoconstriction ( J:141641 )
• mice exhibit reduced vasocontraction in response to angiotensin II, and endothelin-1 compared to in similarly treated wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory