Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6/tetO-POSTN)22.1Jmol
• Allele Name: transgene insertion 22.1, Jeffery D Molkentin
• Allele ID: MGI:3819377
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Myh6/tetO-POSTN)22.1Jmol/0 Tg(Myh6-tTA)55Rbns/0	involves: FVB/N	MGI:3819379

Genotype
MGI:3819379

cx1

• Allelic Composition: Tg(Myh6/tetO-POSTN)22.1Jmol/0; Tg(Myh6-tTA)55Rbns/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:140301 )

N • despite cardiac hypertrophy, mice exhibit normal ventricular performance

increased heart weight ( J:140301 )

• by 24 weeks of age, ventricular weight normalized to body weight is increased compared to in wild-type mice

cardiac hypertrophy ( J:140301 )

• by 24 weeks of age, mice exhibit cardiac hypertrophy compared to wild-type mice

• following transverse aortic constriction to induce pressure overload, mice exhibit more cardiac hypertrophy with increased myocyte cross-section diameter after 8 weeks compared to similarly treated wild-type mice

abnormal response to cardiac infarction ( J:140301 )

• mice are protected from ventricular wall rupture following induced myocardial infarct unlike wild-type mice

homeostasis/metabolism

abnormal response to cardiac infarction ( J:140301 )

• mice are protected from ventricular wall rupture following induced myocardial infarct unlike wild-type mice

increased susceptibility to injury ( J:140301 )

• following transverse aortic constriction to induce pressure overload, mice exhibit more cardiac hypertrophy with increased myocyte cross-section diameter after 8 weeks compared to similarly treated wild-type mice

growth/size/body

increased heart weight ( J:140301 )

• by 24 weeks of age, ventricular weight normalized to body weight is increased compared to in wild-type mice

cardiac hypertrophy ( J:140301 )

• by 24 weeks of age, mice exhibit cardiac hypertrophy compared to wild-type mice

• following transverse aortic constriction to induce pressure overload, mice exhibit more cardiac hypertrophy with increased myocyte cross-section diameter after 8 weeks compared to similarly treated wild-type mice