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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Telo2tm1Tdl
targeted mutation 1, Titia de Lange
MGI:3819389
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Telo2tm1Tdl/Telo2tm1.1Tdl
Trp53tm1Tyj/Trp53tm1Tyj
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ 		involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J MGI:3819400
cn2
 		Telo2tm1Tdl/Telo2tm1.1Tdl
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ 		involves: 129 * 129P2/OlaHsd * C57BL/6J MGI:3819399


Genotype
MGI:3819400
cn1
Allelic
Composition		 Telo2tm1Tdl/Telo2tm1.1Tdl
Trp53tm1Tyj/Trp53tm1Tyj
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Telo2tm1.1Tdl mutation (0 available); any Telo2 mutation (33 available)
Telo2tm1Tdl mutation (0 available); any Telo2 mutation (33 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle ( J:141633 )
• tamoxifen-treated mouse embryonic fibroblasts exhibit cell cycle arrest after 6 days in culture unlike wild-type cells




Genotype
MGI:3819399
cn2
Allelic
Composition		 Telo2tm1Tdl/Telo2tm1.1Tdl
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Telo2tm1.1Tdl mutation (0 available); any Telo2 mutation (33 available)
Telo2tm1Tdl mutation (0 available); any Telo2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle ( J:141633 )
• after 3 to 4 days in culture tamoxifen-treated mouse embryonic fibroblasts (MEFs) arrest with 2N or 4N DNA content and exhibit reduced S and M phase unlike wild-type MEFs
early cellular replicative senescence ( J:141633 )
• after 3 to 4 days in culture tamoxifen-treated mouse embryonic fibroblasts (MEFs) exhibit a flattened senescence-like morphology unlike wild-type MEFs
abnormal DNA repair ( J:141633 )
• tamoxifen-treated mouse embryonic fibroblasts exhibit decreased DNA-damage signaling via Trp53, Cdkn1a and Chek1 compared to wild-type cells

homeostasis/metabolism
abnormal DNA repair ( J:141633 )
• tamoxifen-treated mouse embryonic fibroblasts exhibit decreased DNA-damage signaling via Trp53, Cdkn1a and Chek1 compared to wild-type cells




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory