Analysis Tools
mortality/aging
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• mice die within 48 hours of birth
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homeostasis/metabolism
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• cholesterol levels are improved compared to in Dhcr7tm1Gst homozygotes but still less than in wild-type mice
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• cholesterol levels in the brain are decreased
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• cholesterol levels in liver are 80% to 90% of normal
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• cholesterol levels in the lungs are 80% to 90% of normal
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respiratory system
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• cholesterol levels in the lungs are 80% to 90% of normal
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• mice exhibit reduced sac space formation and thickening of the pre-alveolar septae that is not as severe as in Dhcr7tm1Gst homozogotes
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behavior/neurological
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• some mice exhibit poor suckling reflexes compared to in wild-type mice
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muscle
liver/biliary system
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• cholesterol levels in liver are 80% to 90% of normal
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nervous system
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• cholesterol levels in the brain are decreased
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