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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox4Igt4
Impaired glucose tolerance 4
MGI:3819788
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sox4Igt4/Sox4Igt4 involves: C3H/HeH * C57BL/6 MGI:3819946
ht2
 		Sox4Igt4/Sox4+ involves: C3H/HeH * C57BL/6 MGI:3819942
ht3
 		Sox4Igt4/Sox4M91Ark involves: C3H/HeH * C57BL/6 MGI:3819945
cx4
 		Sox4Igt4/Del(13)36H involves: 101/H * C3H/HeH * C57BL/6 MGI:3819947
cx5
 		Insrtm1Dac/Insr+
Sox4Igt4/Sox4+ 		involves: C3H/HeH * C57BL/6 MGI:3819939


Genotype
MGI:3819946
hm1
Allelic
Composition		 Sox4Igt4/Sox4Igt4
Genetic
Background		 involves: C3H/HeH * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox4Igt4 mutation (1 available); any Sox4 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3819942
ht2
Allelic
Composition		 Sox4Igt4/Sox4+
Genetic
Background		 involves: C3H/HeH * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox4Igt4 mutation (1 available); any Sox4 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased insulin secretion ( J:141688 )
• the amount of insulin secreted by beta-islet cells in response to glucose is much less with a 70% reduction in the amount secreted in response to 20 mmol glucose
decreased circulating insulin level ( J:141688 )
• circulating insulin levels are significantly lower 10 to 30 minutes after a glucose challenge
impaired glucose tolerance ( J:141688 )
• these mice have impaired glucose tolerance with glucose levels significantly higher 60 minutes after glucose administration

endocrine/exocrine glands
decreased insulin secretion ( J:141688 )
• the amount of insulin secreted by beta-islet cells in response to glucose is much less with a 70% reduction in the amount secreted in response to 20 mmol glucose




Genotype
MGI:3819945
ht3
Allelic
Composition		 Sox4Igt4/Sox4M91Ark
Genetic
Background		 involves: C3H/HeH * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox4Igt4 mutation (1 available); any Sox4 mutation (23 available)
Sox4M91Ark mutation (2 available); any Sox4 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3819947
cx4
Allelic
Composition		 Sox4Igt4/Del(13)36H
Genetic
Background		 involves: 101/H * C3H/HeH * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Sox4Igt4 mutation (1 available); any Sox4 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
interrupted aortic arch ( J:141688 )
• hypoplastic or interrupted aortic arches are observed in E14.5 fetuses
double outlet right ventricle ( J:141688 )
• the aorta and pulmonary artery both originate from the right ventricle
abnormal atrioventricular valve morphology ( J:141688 )
• the atrioventricular valves of E14.5 embryos are dysplastic
subarterial ventricular septal defect ( J:141688 )
• a large outlet ventricular septum defect connects the left and right ventricles

craniofacial
cleft palate ( J:141688 )
• 60% of E14.5 embryos have cleft palate

digestive/alimentary system
cleft palate ( J:141688 )
• 60% of E14.5 embryos have cleft palate

hematopoietic system
thymus hypoplasia ( J:141688 )
• bilateral hypoplasia of the thymus is noted in one case

homeostasis/metabolism
extremity edema ( J:141688 )
• severe edema is observed in the extremities of the E14.5 fetus

immune system
thymus hypoplasia ( J:141688 )
• bilateral hypoplasia of the thymus is noted in one case

renal/urinary system
renal hypoplasia ( J:141688 )
• bilateral renal hypoplasia is noted in one case

endocrine/exocrine glands
thymus hypoplasia ( J:141688 )
• bilateral hypoplasia of the thymus is noted in one case

growth/size/body
cleft palate ( J:141688 )
• 60% of E14.5 embryos have cleft palate




Genotype
MGI:3819939
cx5
Allelic
Composition		 Insrtm1Dac/Insr+
Sox4Igt4/Sox4+
Genetic
Background		 involves: C3H/HeH * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insrtm1Dac mutation (2 available); any Insr mutation (95 available)
Sox4Igt4 mutation (1 available); any Sox4 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
impaired glucose tolerance ( J:141688 )
• these mice have impaired glucose tolerance with glucose levels significantly higher than controls 60 and 120 minutes after glucose administration
• the glucose levels are higher than in mice carrying the mutant Sox4 allele on a background that is homozygote for the wild-type allele of Insr




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory