All Phenotypes Sox4<M91Ark> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sox4^M91Ark
mutation 91, Ruth M Arkell
MGI:3819793

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Sox4^M91Ark/Sox4⁺	involves: C3H/HeH	MGI:3819948
ht2	Sox4^Igt4/Sox4^M91Ark	involves: C3H/HeH * C57BL/6	MGI:3819945
cx3	Foxq1^sa/Foxq1⁺ Sox4^M91Ark/Del(13)36H	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:3819858
cx4	Foxq1^sa/Foxq1⁺ Sox4^M91Ark/Sox4⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516058

Allelic Composition	Sox4^M91Ark/Sox4⁺
Genetic Background	involves: C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox4^M91Ark mutation (2 available); any Sox4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased insulin secretion ( J:141688 )

• the amount of insulin secreted by beta-islet cells in response to glucose is much less with a 70% reduction in the amount secreted in response to 20 mmol glucose

homeostasis/metabolism

decreased insulin secretion ( J:141688 )

• the amount of insulin secreted by beta-islet cells in response to glucose is much less with a 70% reduction in the amount secreted in response to 20 mmol glucose

decreased circulating insulin level ( J:141688 )

• circulating insulin levels are significantly lower 10 to 30 minutes after a glucose challenge

impaired glucose tolerance ( J:141688 )

• these mice have impaired glucose tolerance with glucose levels significantly higher 60 minutes after glucose administration

Allelic Composition	Sox4^Igt4/Sox4^M91Ark
Genetic Background	involves: C3H/HeH * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox4^Igt4 mutation (1 available); any Sox4 mutation (23 available)
Sox4^M91Ark mutation (2 available); any Sox4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:141688 )

• mice die in utero around E14.5

Allelic Composition	Foxq1^sa/Foxq1⁺ Sox4^M91Ark/Del(13)36H
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (29 available)
Sox4^M91Ark mutation (2 available); any Sox4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:101156 )

• almost all mice die before birth, with a significant deviation from expected Mendelian frequencies first noted at E14.5

cardiovascular system

abnormal aortic arch morphology ( J:101156 )

• smaller than the pulmonary artery

abnormal cardiovascular development ( J:101156 )

• circulatory failure

abnormal heart morphology ( J:101156 )

abnormal heart development ( J:101156 )

• common atrioventricular junction

double outlet right ventricle ( J:101156 )

• the aorta and pulmonary artery both originate from the right ventricle

abnormal mitral valve morphology ( J:101156 )

• the mitral valve of E14.5 embryos is dysplastic

ostium primum atrial septal defect ( J:101156 )

• a primum atrial septal defect is seen at the ventral margin of the primary atrial septum in E14.5 embryos

ventricular septal defect ( J:101156 )

• a large ventricular septum defect connects the left and right ventricles

renal/urinary system

abnormal kidney development ( J:101156 )

• kidneys of E14.5 embryos are hypoplastic and occasionally positioned abnormally

renal hypoplasia ( J:101156 )

nervous system

holoprosencephaly ( J:101156 )

Allelic Composition	Foxq1^sa/Foxq1⁺ Sox4^M91Ark/Sox4⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxq1^sa mutation (16 available); any Foxq1 mutation (29 available)
Sox4^M91Ark mutation (2 available); any Sox4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased anxiety-related response ( J:101156 )

• mice have a 31% decrease compared to controls in how many times the central portion of an open field test is entered

• mice also have additional reductions in total distance traveled (22% decrease) and movement time (14% decrease) in the open field tests

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24