Phenotypes associated with this allele

• Allele Symbol: Nalcn^tm1.1Dren
• Allele Name: targeted mutation 1.1, Dejian Ren
• Allele ID: MGI:3819820
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nalcn^tm1.1Dren/Nalcn^tm1.1Dren	involves: C57BL/6	MGI:3819846

Genotype
MGI:3819846

hm1

• Allelic Composition: Nalcn^tm1.1Dren/Nalcn^tm1.1Dren
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:141581 )

• mice die within 24 hours of birth

nervous system

abnormal nervous system electrophysiology ( J:141581 )

• nerve membranes are hyperpolarized compared to in wild-type mice

• neuron membrane potentials are insensitive to changes in sodium concentration unlike in wild-type neurons

abnormal nerve conduction ( J:141581 )

• normal rhythmic electrical activities in the fourth cervical nerve root (C4) are absent

abnormal channel response ( J:141581 )

• mice lack a Cesium+ and TTX-insensitive sodium leak current unlike in wild-type mice

respiratory system

abnormal breathing pattern ( J:141581 )

• at birth, mice exhibit sporadic breathing with a few seconds of apnea before a burst of deep breathing lasting 5 to 10 seconds

apnea ( J:141581 )

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:141581 )

• Gadolinium³⁺ fails to block continuous nerve firing as in wild-type mice

• verapamil is less effective at blocking nerve firing compared to in wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:141581 )

N • mice exhibit normal righting response, spontaneous movement and toe/tail pinch response 12 hour after birth

embryo

embryo phenotype ( J:141581 )

N • embryonic development is grossly normal