Analysis Tools
hematopoietic system
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• the numbers of Ter119+ GR1+ and Mac1+ cells are increased in the spleen compared to in wild-type mice
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• mice exhibit hyperplasia of erythroid-myeloid cells unlike in wild-type mice
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• half of circulating erythrocytes contain mitochondria unlike in wild-type erythrocytes
• erythrocytes that develop from bone marrow transplanted into wild-type recipients exhibits increased mitochondria content compared to in wild-type cells
• however, erythrocytes clear their ribosomes normally
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cellular
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• cultured reticulocytes exhibit abnormal autophagy of mitochrondria with mitochondria associated with the outer membrane of the autophagosome and undegraded autophagosome content unlike in wild-type reticulocytes
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immune system
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• the numbers of Ter119+ GR1+ and Mac1+ cells are increased in the spleen compared to in wild-type mice
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growth/size/body
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• the numbers of Ter119+ GR1+ and Mac1+ cells are increased in the spleen compared to in wild-type mice
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homeostasis/metabolism
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• cultured reticulocytes exhibit abnormal autophagy of mitochrondria with mitochondria associated with the outer membrane of the autophagosome and undegraded autophagosome content unlike in wild-type reticulocytes
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