Analysis Tools
mortality/aging
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• at E15-17, the wild-type/heterozygote/homozygote frequency is 1:1.6:0.3, indicating further lethality
• at E18-19, the wild-type/heterozygote/homozygote frequency is 1:1.6:0.08, indicating lethality in late development
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• first loss of embryos occurs between E10 and E14, with a wild-type/heterozygote/homozygote frequency of 1:1.5:0.4
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growth/size/body
omphalocele
(
J:141575
)
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• seen in some mutants at E81.5
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embryo
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• a few mutants show decreased number and caliber of vessels in yolk sacs
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cardiovascular system
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• a few mutants show decreased number and caliber of vessels in yolk sacs
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• 57% of surviving embryos between E13.5 and E14.5 exhibit a double-outlet right ventricle
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• 71% penetrance of a ventricular septal defect (VSD) by E14.5; most mutants with double-outlet right ventricle exhibit the VSD
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• 71% of mutants exhibit pronounced pericardial edema by E14.5
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hypovolemia
(
J:141575
)
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• by E14.5-15, surviving mutants show a decreased volume of blood in vessels in the head and extremities
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hemorrhage
(
J:141575
)
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• some mutants exhibit hemorrhaging between E14.5 and E18.5
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homeostasis/metabolism
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• 71% of mutants exhibit pronounced pericardial edema by E14.5
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integument
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• some mutants exhibit petechiae along the surface of their bodies near the head and upper torso between E14.5 and E18.5
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