Phenotypes associated with this allele

• Allele Symbol: Bnip3l^tm1.1Gwd
• Allele Name: targeted mutation 1.1, Gerald W Dorn
• Allele ID: MGI:3819954
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bnip3l^tm1.1Gwd/Bnip3l^tm1.1Gwd	involves: 129	MGI:4430399
hm2	Bnip3l^tm1.1Gwd/Bnip3l^tm1.1Gwd	involves: 129 * C57BL/6	MGI:3819957
cx3	Bnip3l^tm1.1Gwd/Bnip3l^tm1.1Gwd Tg(Myh6-Gnaq)#Gwd/0	involves: 129 * FVB/N	MGI:4430400

Genotype
MGI:4430399

hm1

• Allelic Composition: Bnip3l^tm1.1Gwd/Bnip3l^tm1.1Gwd
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:145086 )

N • no cardiac abnormalities are detected

Genotype
MGI:3819957

hm2

• Allelic Composition: Bnip3l^tm1.1Gwd/Bnip3l^tm1.1Gwd
• Genetic Background: involves: 129 * C57BL/6

growth/size/body

decreased body weight ( J:141583 )

• 16% reduction in body mass

decreased body length ( J:141583 )

• 9% reduction in nose to anus body length

postnatal growth retardation ( J:141583 )

• modest growth retardation

enlarged spleen ( J:141583 )

hematopoietic system

abnormal definitive hematopoiesis ( J:141583 )

abnormal thrombopoiesis ( J:141583 )

• increased number of platelets in the peripheral circulation

abnormal bone marrow cell number ( J:141583 )

abnormal erythroblast number ( J:141583 )

• increased numbers of erythroblasts in early and mid maturation

• reduced apoptosis of basophilic and chromophilic erythroblasts

• proportional reduction of orthochromatic erythroblasts

abnormal erythrocyte morphology ( J:141583 )

• in the peripheral circulation

increased mean corpuscular volume ( J:141583 )

anisocytosis ( J:141583 )

poikilocytosis ( J:141583 )

polychromatophilia ( J:141583 )

reticulocytosis ( J:141583 )

• increased number of reticulocytes in peripheral blood

abnormal spleen morphology ( J:141583 )

enlarged spleen ( J:141583 )

increased spleen red pulp amount ( J:141583 )

• 2-3 fold increase in spleen erythroblast mass

immune system

abnormal thrombopoiesis ( J:141583 )

• increased number of platelets in the peripheral circulation

abnormal spleen morphology ( J:141583 )

enlarged spleen ( J:141583 )

increased spleen red pulp amount ( J:141583 )

• 2-3 fold increase in spleen erythroblast mass

Genotype
MGI:4430400

cx3

• Allelic Composition: Bnip3l^tm1.1Gwd/Bnip3l^tm1.1Gwd; Tg(Myh6-Gnaq)#Gwd/0
• Genetic Background: involves: 129 * FVB/N

mortality/aging

premature death ( J:145086 )

• mice exhibit premature death with wild-type mice that is not as severe as in Tg(Myh6-Gnaq)Gwd mice

cardiovascular system

cardiovascular system phenotype ( J:145086 )

N • mice do not exhibit ventricular remodeling unlike Tg(Myh6-Gnaq)Gwd mice

enlarged heart ( J:145086 )

• not as severe as in Tg(Myh6-Gnaq)Gwd mice

dilated heart ( J:145086 )

• not as severe as in Tg(Myh6-Gnaq)Gwd mice

decreased cardiac muscle contractility ( J:145086 )

• not as severe as in Tg(Myh6-Gnaq)Gwd mice

muscle

decreased cardiac muscle contractility ( J:145086 )

• not as severe as in Tg(Myh6-Gnaq)Gwd mice

increased cardiomyocyte apoptosis ( J:145086 )

• not as severe as in Tg(Myh6-Gnaq)Gwd mice

cellular

increased cardiomyocyte apoptosis ( J:145086 )

• not as severe as in Tg(Myh6-Gnaq)Gwd mice

growth/size/body

enlarged heart ( J:145086 )

• not as severe as in Tg(Myh6-Gnaq)Gwd mice