Analysis Tools
mortality/aging
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• 50% of mice die within 30 days of birth, possibly from thrombi in the right atria
• 20% of mice die within 120 days
• mice with less multi-organ inflammation live longer
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growth/size/body
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• body weights are 25-35% less than controls at 4 and 12 weeks of age
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immune system
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• no Langerhans cells are present in the back skin epidermis of 21 week old mice
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• mice develop multi-organ inflammation to varying degrees depending on the individual
• mice with less inflammation tend to live longer and develop less tumors
• in general, inflammation in these mice are less severe than those observed in Tgfb1 null homozygotes
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• inflammatory infiltrate is observed in the heart
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• inflammatory infiltrate is found in the lamina propria and surrounding crypts
• inflammation in the large intestine is first observable 5 weeks after birth
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• inflammation in the cecum is first observable 5 weeks after birth
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• inflammatory infiltrate is found in the lamina propria and surrounding crypts
• inflammation in the rectum is first observable 5 weeks after birth
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• inflammation in the small intestine is first observable 5 weeks after birth
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• inflammation in the stomach is first observable 5 weeks after birth
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• inflammation occurs around large blood vessels and large airways
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neoplasm
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• 40% of mice develop neoplasms by 8 weeks of age
• tumor development correlates with severity of multi-organ inflammation
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• 10% of mice develop anal carcinomas
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• terminal colon/rectal adenocarcinomas develop in 8% of mice
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• terminal colon/rectal adenocarcinomas develop in 8% of mice
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• gastric papillomas are observed in the forestomach of about 24% of mice
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• are observed in the glandular stomach of about 8% of mice
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digestive/alimentary system
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• higher number of stomach and rectum epithelial cells are actively dividing compared to controls
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• 10% of mice develop anal carcinomas
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• terminal colon/rectal adenocarcinomas develop in 8% of mice
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• terminal colon/rectal adenocarcinomas develop in 8% of mice
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• gastric papillomas are observed in the forestomach of about 24% of mice
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• are observed in the glandular stomach of about 8% of mice
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• inflammatory infiltrate is found in the lamina propria and surrounding crypts
• inflammation in the large intestine is first observable 5 weeks after birth
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• inflammation in the cecum is first observable 5 weeks after birth
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• inflammatory infiltrate is found in the lamina propria and surrounding crypts
• inflammation in the rectum is first observable 5 weeks after birth
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• inflammation in the small intestine is first observable 5 weeks after birth
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• inflammation in the stomach is first observable 5 weeks after birth
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cardiovascular system
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• inflammatory infiltrate is observed in the heart
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respiratory system
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• inflammation occurs around large blood vessels and large airways
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hematopoietic system
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• no Langerhans cells are present in the back skin epidermis of 21 week old mice
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