Phenotypes associated with this allele

• Allele Symbol: Tg(Cela1-cre/ERT2)1Stof
• Allele Name: transgene insertion 1, Doris A Stoffers
• Allele ID: MGI:3820514
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kras^tm4Tyj/Kras^tm4Tyj Tg(Cela1-cre/ERT2)1Stof/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:3821737

Genotype
MGI:3821737

cn1

• Allelic Composition: Kras^tm4Tyj/Kras^tm4Tyj; Tg(Cela1-cre/ERT2)1Stof/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pancreatic intraepithelial neoplasia incidence ( J:142189 )

• 2 months after injection with tamoxifen, 50% of mice exhibit focal low grade pancreatic intraepithelial neoplasia (PanIN) that progresses to carcinoma in situ by 4 to 12 months following injection with tamoxifen

• tamoxifen treated mice exhibit lesions that progress from normal acinar parenchyma to acinar-ductal metaplastic structures to PanIN with biphenotypic exocrine differentiation

• tamoxifen treated mice exhibit highly proliferative acinar derived PanIN

endocrine/exocrine glands

increased pancreatic intraepithelial neoplasia incidence ( J:142189 )

• 2 months after injection with tamoxifen, 50% of mice exhibit focal low grade pancreatic intraepithelial neoplasia (PanIN) that progresses to carcinoma in situ by 4 to 12 months following injection with tamoxifen

• tamoxifen treated mice exhibit lesions that progress from normal acinar parenchyma to acinar-ductal metaplastic structures to PanIN with biphenotypic exocrine differentiation

• tamoxifen treated mice exhibit highly proliferative acinar derived PanIN