All Phenotypes Stk4<Gt(AJ0315)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Stk4^{Gt(AJ0315)Wtsi}
gene trap AJ0315, Wellcome Trust Sanger Institute
MGI:3820519

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi}	B6.129P2-Stk4^{Gt(AJ0315)Wtsi}	MGI:3822810
hm2	Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi}	involves: 129 * C57BL/6	MGI:4411984
hm3	Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi}	involves: 129P2/OlaHsd * C57BL/6J	MGI:3820529
cn4	Stk3^tm1Jav/Stk3^tm1Jav Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129 * 129P2/OlaHsd * C57BL/6 * DBA	MGI:5824005
cn5	Stk3^tm1Jav/Stk3^tm1Jav Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi}	involves: 129 * C57BL/6	MGI:4411989
cn6	Stk3^tm1.1Jav/Stk3^tm1Jav Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi}	involves: 129 * C57BL/6	MGI:4411990
cn7	Stk3^tm1Jav/Stk3^tm1Jav Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129 * C57BL/6	MGI:4411991
cn8	Stk3^tm1Jav/Stk3^tm1Jav Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi} Tg(KRT14-cre)1Amc/0	involves: C57BL/6 * CBA	MGI:5316469
cx9	Stk3^tm1.1Jav/Stk3^tm1.1Jav Stk4^{Gt(AJ0315)Wtsi}/Stk4⁺	involves: 129 * C57BL/6	MGI:4411988
cx10	Stk3^tm1.1Jav/Stk3⁺ Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi}	involves: 129 * C57BL/6	MGI:4411987
cx11	Stk3^tm1.1Jav/Stk3^tm1.1Jav Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi}	involves: 129 * C57BL/6	MGI:4411986

Allelic Composition	Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi}
Genetic Background	B6.129P2-Stk4^{Gt(AJ0315)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk4^{Gt(AJ0315)Wtsi} mutation (0 available); any Stk4 mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell apoptosis ( J:142674 )

• in vivo, nave and effector T cells have an apoptosis rate that is twice that of controls

• effector T cells also have an increased rate in apoptosis in vitro after stimulation, though nave T cells have a decreased rate of apoptosis in vitro

increased T cell proliferation ( J:142674 )

• naive T cells proliferate two- to five- fold greater in response to anti-CD3 while memory and effector T cells proliferate at a rate similar to controls

abnormal T cell differentiation ( J:142674 )

• there is a marked reduction in the number of T cells displaying the CD62L^hi/CD44^lo/ nave phenotype in the spleen, lymph nodes and circulation

• numbers of effector/memory T cells are similar or slightly increased in the secondary lymph node tissues compared to controls

• an increase in the number of CD4⁺ effector cells is observed in the lung

decreased CD4-positive, alpha-beta T cell number ( J:142674 )

• the percent and absolute numbers of CD4⁺ T cells in the blood are reduced by a half to two-thirds

• CD4⁺ T cell numbers are also reduced in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:142674 )

• the percent and absolute numbers of CD8⁺ T cells in the blood are reduced by a half to two-thirds

• CD8⁺ T cell numbers are also reduced in the spleen

abnormal memory T cell number ( J:142674 )

• numbers of effector/memory T cells are similar or slightly increased in the secondary lymph node tissues compared to controls

decreased spleen white pulp amount ( J:142674 )

• the amount of white pulp is reduced

increased interferon-gamma secretion ( J:142674 )

• nave and effector CD4⁺ T cells have enhanced production of IFN-gamma in response to anti-CD3 stimulation

increased interleukin-2 secretion ( J:142674 )

• nave and effector CD4⁺ T cells have enhanced production of IL-2 in response to anti-CD3 stimulation

increased interleukin-4 secretion ( J:142674 )

• nave and effector CD4⁺ T cells have enhanced production of IL-4 in response to anti-CD3 stimulation

hematopoietic system

increased T cell apoptosis ( J:142674 )

• in vivo, nave and effector T cells have an apoptosis rate that is twice that of controls

• effector T cells also have an increased rate in apoptosis in vitro after stimulation, though nave T cells have a decreased rate of apoptosis in vitro

increased T cell proliferation ( J:142674 )

• naive T cells proliferate two- to five- fold greater in response to anti-CD3 while memory and effector T cells proliferate at a rate similar to controls

abnormal T cell differentiation ( J:142674 )

• there is a marked reduction in the number of T cells displaying the CD62L^hi/CD44^lo/ nave phenotype in the spleen, lymph nodes and circulation

• numbers of effector/memory T cells are similar or slightly increased in the secondary lymph node tissues compared to controls

• an increase in the number of CD4⁺ effector cells is observed in the lung

decreased CD4-positive, alpha-beta T cell number ( J:142674 )

• the percent and absolute numbers of CD4⁺ T cells in the blood are reduced by a half to two-thirds

• CD4⁺ T cell numbers are also reduced in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:142674 )

• the percent and absolute numbers of CD8⁺ T cells in the blood are reduced by a half to two-thirds

• CD8⁺ T cell numbers are also reduced in the spleen

abnormal memory T cell number ( J:142674 )

• numbers of effector/memory T cells are similar or slightly increased in the secondary lymph node tissues compared to controls

decreased spleen white pulp amount ( J:142674 )

• the amount of white pulp is reduced

cellular

increased T cell apoptosis ( J:142674 )

• in vivo, nave and effector T cells have an apoptosis rate that is twice that of controls

• effector T cells also have an increased rate in apoptosis in vitro after stimulation, though nave T cells have a decreased rate of apoptosis in vitro

increased T cell proliferation ( J:142674 )

• naive T cells proliferate two- to five- fold greater in response to anti-CD3 while memory and effector T cells proliferate at a rate similar to controls

Allelic Composition	Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi}
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk4^{Gt(AJ0315)Wtsi} mutation (0 available); any Stk4 mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased histiocytic sarcoma incidence ( J:153945 )

• 2 out of 23 mice develop lethal histiocytic sarcomas over a period of 18-24 months

Allelic Composition	Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk4^{Gt(AJ0315)Wtsi} mutation (0 available); any Stk4 mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:140710 )

N	• mice are viable and fertile

Allelic Composition	Stk3^tm1Jav/Stk3^tm1Jav Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129 * 129P2/OlaHsd * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)
Stk3^tm1Jav mutation (0 available); any Stk3 mutation (49 available)
Stk4^{Gt(AJ0315)Wtsi} mutation (0 available); any Stk4 mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

increased hepatocellular carcinoma incidence ( J:238319 )

• mice develop multiple spontaneous hepatocellular carcinomas

neoplasm

increased hepatocellular carcinoma incidence ( J:238319 )

• mice develop multiple spontaneous hepatocellular carcinomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:238319

Allelic Composition	Stk3^tm1Jav/Stk3^tm1Jav Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi}
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3^tm1Jav mutation (0 available); any Stk3 mutation (49 available)
Stk4^{Gt(AJ0315)Wtsi} mutation (0 available); any Stk4 mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

increased hepatocyte proliferation ( J:153945 )

• 4-fold increase in hepatocyte proliferation by Ki-67 staining at day 8 after Adeno-Cre administration

liver hyperplasia ( J:153945 )

• injecting of Adenovirus expressing Cre recombinase (Adeno-Cre) into the tail vein at 6 weeks old to induce liver-specific deletion

• a prominent increase in liver size as early as 3 days after Adeno-Cre administration

• 2-fold larger at 8 days and 4-fold larger by 3 months

increased hepatocellular carcinoma incidence ( J:153945 )

• with a mean latency of 10 weeks after Adeno-Cre injection

• the presence of multifocal hepatocellular carcinomas (HCCs) against the backdrop of hyperplastic, but untransformed, hepatocytes

neoplasm

increased hepatocellular carcinoma incidence ( J:153945 )

• with a mean latency of 10 weeks after Adeno-Cre injection

• the presence of multifocal hepatocellular carcinomas (HCCs) against the backdrop of hyperplastic, but untransformed, hepatocytes

cellular

increased hepatocyte proliferation ( J:153945 )

• 4-fold increase in hepatocyte proliferation by Ki-67 staining at day 8 after Adeno-Cre administration

growth/size/body

liver hyperplasia ( J:153945 )

• injecting of Adenovirus expressing Cre recombinase (Adeno-Cre) into the tail vein at 6 weeks old to induce liver-specific deletion

• a prominent increase in liver size as early as 3 days after Adeno-Cre administration

• 2-fold larger at 8 days and 4-fold larger by 3 months

Allelic Composition	Stk3^tm1.1Jav/Stk3^tm1Jav Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi}
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3^tm1.1Jav mutation (0 available); any Stk3 mutation (49 available)
Stk3^tm1Jav mutation (0 available); any Stk3 mutation (49 available)
Stk4^{Gt(AJ0315)Wtsi} mutation (0 available); any Stk4 mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

increased hepatocyte proliferation ( J:153945 )

• 4-fold increase in hepatocyte proliferation by Ki-67 staining at day 8 after Adeno-Cre administration

liver hyperplasia ( J:153945 )

• injecting of Adenovirus expressing Cre recombinase (Adeno-Cre) into the tail vein at 6 weeks old to induce liver-specific deletion

• a prominent increase in liver size as early as 3 days after Adeno-Cre administration

• 2-fold larger at 8 days and 4-fold larger by 3 months

increased hepatocellular carcinoma incidence ( J:153945 )

• with a mean latency of 10 weeks after Adeno-Cre injection

• the presence of multifocal hepatocellular carcinomas (HCCs) against the backdrop of hyperplastic, but untransformed, hepatocytes

neoplasm

increased hepatocellular carcinoma incidence ( J:153945 )

• with a mean latency of 10 weeks after Adeno-Cre injection

• the presence of multifocal hepatocellular carcinomas (HCCs) against the backdrop of hyperplastic, but untransformed, hepatocytes

cellular

decreased sensitivity to induced cell death ( J:153945 )

• resistance to Fas-Induced Apoptosis in the liver as determined by histological examination, TUNEL staining and western blotting for cleaved caspase-3

increased hepatocyte proliferation ( J:153945 )

• 4-fold increase in hepatocyte proliferation by Ki-67 staining at day 8 after Adeno-Cre administration

growth/size/body

liver hyperplasia ( J:153945 )

• injecting of Adenovirus expressing Cre recombinase (Adeno-Cre) into the tail vein at 6 weeks old to induce liver-specific deletion

• a prominent increase in liver size as early as 3 days after Adeno-Cre administration

• 2-fold larger at 8 days and 4-fold larger by 3 months

Allelic Composition	Stk3^tm1Jav/Stk3^tm1Jav Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

liver hyperplasia ( J:153945 )

• develop massively overgrown livers by 3 months of age (4 out of 4)

increased hepatocellular carcinoma incidence ( J:153945 )

• develop hepatocellular carcinomas (HHCs) by 3 months of age (4 out of 4)

neoplasm

increased hepatocellular carcinoma incidence ( J:153945 )

• develop hepatocellular carcinomas (HHCs) by 3 months of age (4 out of 4)

growth/size/body

liver hyperplasia ( J:153945 )

• develop massively overgrown livers by 3 months of age (4 out of 4)

Allelic Composition	Stk3^tm1Jav/Stk3^tm1Jav Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi} Tg(KRT14-cre)1Amc/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:171057 )

N	• mice exhibit normal epidermal development

Allelic Composition	Stk3^tm1.1Jav/Stk3^tm1.1Jav Stk4^{Gt(AJ0315)Wtsi}/Stk4⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3^tm1.1Jav mutation (0 available); any Stk3 mutation (49 available)
Stk4^{Gt(AJ0315)Wtsi} mutation (0 available); any Stk4 mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:153945 )

• highly aggressive hepatocellular carcinomas (HCCs)

• HCCs in 3 out of 12 mice by 15 months of age

• no mice (n = 6) have visible tumors among 7-month-old asymptomatic animals

• Western blotting, PCR analysis of HCCs reveals the absence of wild-type proteins and DNA of both alleles

liver/biliary system

increased hepatocellular carcinoma incidence ( J:153945 )

• highly aggressive hepatocellular carcinomas (HCCs)

• HCCs in 3 out of 12 mice by 15 months of age

• no mice (n = 6) have visible tumors among 7-month-old asymptomatic animals

• Western blotting, PCR analysis of HCCs reveals the absence of wild-type proteins and DNA of both alleles

Allelic Composition	Stk3^tm1.1Jav/Stk3⁺ Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi}
Genetic Background	involves: 129 * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

lethargy ( J:153945 )

• starting at 7 months of age

neoplasm

increased hepatocellular carcinoma incidence ( J:153945 )

• highly aggressive hepatocellular carcinomas (HCCs)

• HCCs in 6 out of 7 asymptomatic mice at 7 months old

• Western blotting, PCR analysis of HCCs reveals the absence of wild-type proteins and DNA of both alleles

• mice that show morbidity (13 out of 16 by 15 months old) harbor liver tumors

liver/biliary system

liver hyperplasia ( J:153945 )

• some mice display overgrowth (2- to 4-fold) of the apparently normal liver tissue

increased hepatocellular carcinoma incidence ( J:153945 )

• highly aggressive hepatocellular carcinomas (HCCs)

• HCCs in 6 out of 7 asymptomatic mice at 7 months old

• Western blotting, PCR analysis of HCCs reveals the absence of wild-type proteins and DNA of both alleles

• mice that show morbidity (13 out of 16 by 15 months old) harbor liver tumors

growth/size/body

liver hyperplasia ( J:153945 )

• some mice display overgrowth (2- to 4-fold) of the apparently normal liver tissue

Allelic Composition	Stk3^tm1.1Jav/Stk3^tm1.1Jav Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi}
Genetic Background	involves: 129 * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:153945 )

• none survive beyond E9.5

embryo

abnormal vitelline vasculature morphology ( J:153945 )

• under-vascularized yolk sacs at E9.5

failure of initiation of embryo turning ( J:153945 )

• failure to turn by E9.5

embryonic growth retardation ( J:153945 )

• first signs of retardation evident at embryonic day 8.5 (E8.5)

decreased embryo size ( J:153945 )

• E8.5 embryos are smaller

open neural tube ( J:153945 )

• failure to close the neural tube by E9.5

pale yolk sac ( J:153945 )

• at E9.5

growth/size/body

embryonic growth retardation ( J:153945 )

• first signs of retardation evident at embryonic day 8.5 (E8.5)

decreased embryo size ( J:153945 )

• E8.5 embryos are smaller

nervous system

open neural tube ( J:153945 )

• failure to close the neural tube by E9.5

cardiovascular system

abnormal vitelline vasculature morphology ( J:153945 )

• under-vascularized yolk sacs at E9.5

enlarged pericardium ( J:153945 )

• at E9.5

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