All Phenotypes Mylk<tm1Mzhu> MGI Mouse

premature death ( J:141907 )

• all mice die within 17 days of the onset of tamoxifen treatment with a paralytic gut

distended abdomen ( J:141907 )

• enlarged abdomen after 5 consecutive days of tamoxifen injections

abnormal urinary bladder physiology ( J:141907 )

• after 5 consecutive days of tamoxifen injections

ischuria ( J:141907 )

• retention of urine late in the course of tamoxifen treatments

abnormal intestine morphology ( J:141907 )

abnormal intestinal smooth muscle morphology ( J:141907 )

• smooth muscle layers of the jejunum are thickened due to enlarged smooth muscle cells

• enlarged muscle layers in the ileum but to a lesser extent than in jejunum

distended ileum ( J:141907 )

• grossly distended after 5 consecutive days of tamoxifen injections

• contains abundant liquid

distended jejunum ( J:141907 )

• grossly distended after 5 consecutive days of tamoxifen injections

• contains abundant liquid

• becomes dilated late in tamoxifen treatment

abnormal digestive system physiology ( J:141907 )

• anal sphincter muscle tension is reduced after 5 consecutive days of tamoxifen injections

abnormal defecation ( J:141907 )

• reduced excretion of feces after 5 consecutive days of tamoxifen injections

abnormal gastrointestinal motility ( J:141907 )

• abnormal gastrointestinal motility after 5 consecutive days of tamoxifen injections

abnormal intestinal peristalsis ( J:141907 )

• contractile tension significantly reduced

• tension development of ileal and jejunal strips is 13% of controls in response to KCl

• 20-28% tension response to acetylcholine which is abolished by atropine treatment

• peristaltic frequency of the ileum increased by 30%

small intestinal inflammation ( J:141907 )

• mucosal inflammation

• elevated bacterial counts

abnormal vertebral column morphology ( J:141907 )

• severe spinal sinuosity after 5 consecutive days of tamoxifen injections

decreased food intake ( J:141907 )

• reduced food intake after 5 consecutive days of tamoxifen injections

decreased systemic arterial blood pressure ( J:141907 )