Phenotypes associated with this allele

• Allele Symbol: Gabpb2^{Gt(RRJ488)Byg}
• Allele Name: gene trap RRJ488, BayGenomics
• Allele ID: MGI:3821584
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gabpb2^Gt(RRJ488)Byg/Gabpb2^Gt(RRJ488)Byg	involves: 129P2/OlaHsd	MGI:3821585

Genotype
MGI:3821585

hm1

• Allelic Composition: Gabpb2^{Gt(RRJ488)Byg}/Gabpb2^{Gt(RRJ488)Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell proliferation ( J:141846 )

• B cells have about a 2-fold higher rate of proliferation than controls when stimulated by anti-IgM due to increased cellular division

increased spleen germinal center number ( J:141846 )

• there is a 33% increase in the number of germinal centers compared to controls 8 days after immunization with sheep red blood cells

• this difference peaks at 12 days with 40% increase in germinal center number

increased IgG1 level ( J:141846 )

• mice have higher levels of antigen-specific IgG1 than in controls after immunization with ovalbumin

increased IgM level ( J:141846 )

• mice have about 50% higher levels of antigen-specific IgM than in controls after immunization with ovalbumin

hematopoietic system

increased B cell proliferation ( J:141846 )

• B cells have about a 2-fold higher rate of proliferation than controls when stimulated by anti-IgM due to increased cellular division

increased spleen germinal center number ( J:141846 )

• there is a 33% increase in the number of germinal centers compared to controls 8 days after immunization with sheep red blood cells

• this difference peaks at 12 days with 40% increase in germinal center number

increased IgG1 level ( J:141846 )

• mice have higher levels of antigen-specific IgG1 than in controls after immunization with ovalbumin

increased IgM level ( J:141846 )

• mice have about 50% higher levels of antigen-specific IgM than in controls after immunization with ovalbumin

cellular

increased B cell proliferation ( J:141846 )

• B cells have about a 2-fold higher rate of proliferation than controls when stimulated by anti-IgM due to increased cellular division