Phenotypes associated with this allele

• Allele Symbol: Ghsr^tm1.1Lex
• Allele Name: targeted mutation 1.1, Lexicon Genetics
• Allele ID: MGI:3821589
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ghsr^tm1.1Lex/Ghsr^tm1.1Lex	involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6	MGI:3821605

Genotype
MGI:3821605

hm1

• Allelic Composition: Ghsr^tm1.1Lex/Ghsr^tm1.1Lex
• Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal digestive system physiology ( J:141985 )

• mice exhibit more pronounced electrical field stimulated-induced on-relaxations and off-contractions in the gastric fundus between 2 and 16 Hz compared to in wild-type mice

• however, fundic contractions following treatment with streptozotocin are the same as in similarly treated wild-type mice

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:141985 )

• following injection with streptozotocin, mice exhibit a delay in the development of hyperphagia, which begins at day 9 instead of day 5 as in similarly treated wild-type mice, and reduced hyperphagia between days 12 and 21 compared to in similarly treated wild-type mice