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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptk2tm1.1Jtpa
targeted mutation 1.1, J Thomas Parsons
MGI:3821611
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ptk2tm1.1Jtpa/Ptk2tm1.1Jtpa B6.129P2-Ptk2tm1.1Jtpa MGI:3821713
hm2
 		Ptk2tm1.1Jtpa/Ptk2tm1.1Jtpa involves: 129P2/OlaHsd * C57BL/6 MGI:3821714


Genotype
MGI:3821713
hm1
Allelic
Composition		 Ptk2tm1.1Jtpa/Ptk2tm1.1Jtpa
Genetic
Background		 B6.129P2-Ptk2tm1.1Jtpa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptk2tm1.1Jtpa mutation (0 available); any Ptk2 mutation (91 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased physiological sensitivity to xenobiotic ( J:142317 )
• bleomycin treated lungs exhibit a 16.5-fold increase in myofibroblast cell area and a 3.2-fold increase in fibroproliferative lesions compared to in similarly treated wild-type mice




Genotype
MGI:3821714
hm2
Allelic
Composition		 Ptk2tm1.1Jtpa/Ptk2tm1.1Jtpa
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptk2tm1.1Jtpa mutation (0 available); any Ptk2 mutation (91 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
muscle phenotype ( J:142495 )
N
• cultured vascular smooth muscle cells exhibit normal formation of focal adhesions




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory